A5020818980- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
Centre National de la Recherche Scientifique
2019-2022
Aix-Marseille Université
2018-2022
Institut de Biologie du Développement Marseille
2022
It is still unclear what drives progression of childhood tumors. During Drosophila larval development, asymmetrically-dividing neural stem cells, called neuroblasts, progress through an intrinsic temporal patterning program that ensures cessation divisions before adulthood. We previously showed also delineates early developmental window during which neuroblasts are susceptible to tumor initiation (Narbonne-Reveau et al., 2016). Using single-cell transcriptomics, clonal analysis and numerical...
COMPASS and Polycomb complexes are antagonistic chromatin that frequently inactivated in cancers, but how these events affect the cellular hierarchy, composition, growth of tumors is unclear. These characteristics can be systematically investigated Drosophila neuroblast which cooption temporal patterning induces a developmental hierarchy confers cancer stem cell (CSC) properties to subset neuroblasts retaining an early larval identity. Here, using single-cell transcriptomics, we reveal...
Abstract The mechanisms that govern the hierarchical organization of tumors are still poorly understood, especially in highly heterogeneous neural cancers. Previously, we had shown aggressive can be induced upon dedifferentiation susceptible intermediate progenitors produced during early development (Narbonne-Reveau et al., 2016). Using clonal analysis, stochastic modelling and single-cell transcriptomics, now find such rapidly become heterogeneous, containing with different proliferative...