A5066232905- Spectroscopy Techniques in Biomedical and Chemical Research
- Algal biology and biofuel production
- Biological Research and Disease Studies
- Spectroscopy and Chemometric Analyses
- Liver Disease Diagnosis and Treatment
- Infrared Thermography in Medicine
- Animal Virus Infections Studies
- Protein Structure and Dynamics
- Enzyme Structure and Function
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Aluminum toxicity and tolerance in plants and animals
- Photodynamic Therapy Research Studies
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Sensors
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Mining Techniques and Economics
- Animal Diversity and Health Studies
- Optical and Acousto-Optic Technologies
- Cassava research and cyanide
- Gallbladder and Bile Duct Disorders
- Optical Imaging and Spectroscopy Techniques
- Wireless Body Area Networks
- Additive Manufacturing and 3D Printing Technologies
Ontario Medical Association
2020
Nautilus Biosciences (Canada)
2014
Indian Institute of Science Bangalore
2003-2008
Ben-Gurion University of the Negev
2000-2005
Oak Ridge National Laboratory
2003-2005
Stanley Medical College
2000
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
The interaction of many lytic cationic antimicrobial peptides with their target cells involves electrostatic interactions, hydrophobic effects, and the formation amphipathic secondary structures, such as α helices or β sheets. We have shown in previous studies that incorporating ≈ 30% d ‐amino acids into a short helical peptide composed leucine lysine preserved activity parent peptide, while hemolytic was abolished. However, mechanisms underlying unique structural features induced by enable...
Due to a rate increase in the resistance of microbial pathogens currently used antibiotics, there is need society for discovery novel antimicrobials. Historically, fungi are proven source antimicrobial compounds. The main goals this study were investigate fungal diversity associated with sea foam collected around coast Prince Edward Island and utility resource production natural products. Obtained isolates identified using ITS nLSU rDNA sequences, fermented on four media, extracted fractions...
Cholelithiasis is the gallstone disease (GSD) where stones are formed in gallbladder. The main function of gallbladder to concentrate bile by absorption water and sodium. GSD has high prevalence among elderly adults. There three major types gallstones found patients, White, Black Brown. chemical component white cholesterol. brown contain different proportions cholesterol bilirubin. pathogenesis not clearly understood. Analysis composition using various spectroscopic techniques offers clues...
In the last few decades, marine metabolites have been exploited to find commercially viable products in several areas. this article, molecular descriptors [log P, mass, total polar surface area (TPSA), H-bond donor, acceptor, and number of rotatable bonds] for marine-derived cytotoxic were calculated compared with marketed anticancer drugs understand their position drug-like space. Marine-based are divided into highly toxic (HT) moderately (MT) classes. The complied well Lipinski's rule five...
Fourier-transform infrared spectroscopy has shown alterations of spectral characteristics cells and tissues as a result carcinogenesis. The research reported here focuses on the diagnosis cancer in formalin-fixed biopsied tissue for which immunochemistry is not possible when PAP-smear results are to be confirmed. data from two groups patients (a control group diagnosed with cervical cancer) were analyzed. It was found that glucose/phosphate ratio decreases (by 23–49%) RNA/DNA increases...
The early diagnosis and proper identification of cervical squamous intraepithelial lesions plays an important role in a good prognosis for the patient. However, present practice screening based on PAP (Papanicolaou) smear histopathology makes it tedious prone to human errors. We assess validity FTIR microspectroscopy (FTIR-MSP) biopsies as method properly assign correct stage premalignancy patients with symptoms neoplasia. For first time we evaluate spectra different grades neoplasia tandem...
Cannabis sativa is a medicinal plant having very complex matrix composed of mainly cannabinoids and terpenoids. The literature has numerous reports, which indicate that tetrahydrocannabinol (THC) the only major psychoactive metabolite in C. sativa. It important to explore other metabolites possibility exhibiting character various degrees also identify targeting receptors such as opioid, γ amino butyric acid (GABA), glycine, serotonin, nicotine present sativa, smoke phytocannabinoid matrices....
The ability to monitor hydrogen peroxide (H2O2) in aqueous smoke extracts will advance our understanding of the relationship between cigarette smoke-induced oxidative stress, inflammation, and disease help elucidate pathways by which various constituents exert their pathogenic effects. We have demonstrated, for first time, measurement H2O2 production from without prior separation sample. Cigarettes were tested on a commercial smoking machine, such that whole or gas vapor phase was bubbled...
Abstract A novel methodology for the diagnosis of acute infections using FTIR microspectroscopy (FTIR‐MSP) data on blood components and cluster analysis is presented. Blood samples were collected from 11 patients suffering various 16 age‐matched healthy human controls. such as white cells, red plasma isolated standard procedures FTIR‐MSP these was utilized. spectra performed. The obtained three different those cells significantly Cluster analyses averaged provided 100% classification between...
Acute Lymphoblastic Leukemia (ALL) accounts for majority of the childhood leukemia. Outcome children with ALL treatment has improved dramatically. Sensitive techniques are available today detection minimal residual disease in ALL, which provide insight into effective cytotoxic treatment. Here, we present a case study, where lymphocytes isolated from two before and after were characterized using microscopic Fourier Transform Infrared spectroscopy. Significant changes absorbance spectral...
ALUMINIUM exposure has been shown to result in aggregation of microtubule-associated protein tau vitro. In the light recent observations that native random structure is maintained its monomeric and dimeric states as well paired helical filaments characteristic Alzheimer's disease, it likely factors playing a causative role neurofibrillary pathology would not drastically alter conformation protein. We have studied interaction with aluminium using circular dichroism (CD) 27AI, NMR...
By exploiting the fast-growing Internet technology, interactive computing server Water Analysis Package ( WAP , version 2.0) has been updated with more flexible options to better understand role of water O atoms present in three-dimensional macromolecular (protein or nucleic acid) structures. The robust facilitates computation and visualization molecules from various hydration shells, interfacial those that stabilize secondary structural elements. It is also possible detect interactions...
Extramedullary plasmacytoma (EMP) is a rare soft tissue plasma cell tumour, usually presenting as mass within the upper respiratory tract. It most unusual for it to present in posterior medi astinum primary solitary lesion. Discussed here case report of patient who initially presented with musculoskeletal pain. Subsequent investiga tions, however, revealed cause be an EMP; diagnosis was made on finding aggregates cells histological examination speci men. The latter had been obtained by way...
In this work, the development and applications of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo disease diagnosis including oral carcinoma are described. The was based on an OPO multi-wavelength time-resolved detection. pulsed Nd-YAG-pumped (6 ns, 20 Hz) is compact has rapid, broad, uniform tuning range. Time-gated intensified charge-coupled device (ICCD) making use external triggering used to effectively eliminate scattering...