A5016806649- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Non-Invasive Vital Sign Monitoring
- Vascular anomalies and interventions
- Central Venous Catheters and Hemodialysis
- Machine Learning in Healthcare
- Cardiovascular Conditions and Treatments
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Transplantation: Methods and Outcomes
- Library Science and Administration
- Diabetes Management and Research
- Phonocardiography and Auscultation Techniques
- Hemodynamic Monitoring and Therapy
- Vascular Procedures and Complications
- Neonatal Respiratory Health Research
Children's Healthcare of Atlanta
2016-2025
Emory University
2016-2025
Buckinghamshire New University
2024
St. James's Hospital
2023
Augusta University
2021
Children's National
2020-2021
Henrietta Egleston Hospital for Children
2020
Severn Trent (United Kingdom)
2012-2018
Creative Research Enterprises (United States)
2016-2017
AID Atlanta
2016
Diastolic run off into the pulmonary circulation and labile coronary perfusion are thought to contribute morbidity mortality after Norwood procedure (NP). We compared outcomes from use of a RV PA conduit (RV/PA) or modified Blalock-Taussig shunt (BTS), physiologically distinct sources blood flow.Review 56 consecutive patients who underwent with RV/PA (n=36) BTS (n=20) between 2000 2002. Median age was 4.5 days (range 1 40) median weight 3.1 kg 1.8 4.1). The constructed 5-mm conduit. Patients...
OBJECTIVE. Pulmonary vein stenosis is a rare, although often lethal, anomaly. Risk factors for the diagnosis of pulmonary are poorly characterized. In this study we sought to identify associated with stenosis, paying particular attention preterm birth. METHODS. By review cardiac database identified all subjects over 10-year period at our institution. Those children anomalous venous connection were not included. Patient-related variables analyzed their association stenosis. was diagnosed by...
With the improvement of medical data capturing, vast amount continuous patient monitoring data, e.g., electrocardiogram (ECG), real-time vital signs and medications, become available for clinical decision support at intensive care units (ICUs). However, it becomes increasingly challenging to model such due high density heterogeneous types requirement interpretable models.
The distribution of passwords chosen by users has implications for site security, password-handling algorithms and even how are permitted to select passwords. Using password lists from four different web sites, we investigate if Zipf's law is a good description the frequency with which chosen. We use number standard statistics, measure security distributions, see modelling data using simple effective. then consider much distributions each have in common, cracking as metric. This shows that...
Efficient generation of cardiomyocytes from human pluripotent stem cells is critical for their regenerative applications. Microgravity and 3D culture can profoundly modulate cell proliferation survival. Here, we engineered microscale progenitor cardiac spheres exposed the to simulated microgravity using a random positioning machine 3 days during differentiation cardiomyocytes. This process resulted in production highly enriched (99% purity) with high viability (90%) expected functional...
Extracorporeal membrane oxygenation (ECMO) for cardiopulmonary support of critically ill patients is used frequently in the pediatric population. ECMO burdened by complications, including thrombosis and hemorrhage. Here we demonstrate focused location clots, their histologic composition, relationship situ thrombus to local hemodynamics circuits. Pediatric circuits from Children’s Healthcare Atlanta, Emory University (Atlanta, GA) were obtained after removal extracorporeal over a 2.5 year...
Cardiomyocytes derived from human pluripotent stem cells (hPSCs) are a promising cell source for regenerative medicine, disease modeling, and drug discovery, all of which require enriched cardiomyocytes, ideally ones with mature phenotypes. However, current methods typically performed in 2D environments that produce immature cardiomyocytes within heterogeneous populations. Here, we generated 3D aggregates (cardiospheres) differentiation cultures hPSCs using microscale technology rotary...
Deep learning models have achieved expert-level performance in healthcare with an exclusive focus on training accurate models. However, many clinical environments such as intensive care unit (ICU), real-time model serving is equally if not more important than accuracy, because ICU patient simultaneously urgent and expensive. Clinical decisions their timeliness, therefore, directly affect both the outcome cost of care. To make timely decisions, we argue underlying system must be...
The balance of systemic, pulmonary, and coronary blood flow after the Norwood operation for hypoplastic left heart syndrome (HLHS) is critical to early survival. We hypothesized that a right ventricle pulmonary artery conduit (instead systemic shunt) would result in hemodynamic changes consistent with more stable perfusion.Hemodynamic data were obtained during cardiac catheterization before hemi-Fontan procedure from 24 patients HLHS; first 10 had shunt, latter 14 conduit. Significant...
In microgravity, cells undergo profound changes in their properties. However, how human cardiac progenitors respond to space microgravity is unknown. this study, we evaluated the effect of on differentiation induced pluripotent stem cell (hiPSC)-derived compared with 1G cultures International Space Station (ISS). Cryopreserved 3D were cultured for 3 weeks ISS. Compared cultures, had 3-fold larger sphere sizes, 20-fold higher counts nuclei, and increased expression proliferation markers....
Racial disparities in healthcare have been well documented the United States. We hypothesise that there will be a racial variance different clinical variables single-ventricle patients through stages of palliation. Retrospective single-centre study stratified all who reached stage 2 palliation by race: Black and White. Other races were excluded. Demographic characteristics compared, alongside follow-up survival data. Primary outcomes progression to Fontan overall survival. Among 526...
<sec> <title>BACKGROUND</title> Asthma remains one of the most serious chronic diseases childhood. Individuals with severe asthma experience sudden episodes breathlessness due to acute airflow obstruction, leading recurrent Pediatric Intensive Care Unit (PICU) admissions that often result in mechanical ventilation and even death. Existing clinical assessments lack temporal resolution effectively track rapidly changing physiology. </sec> <title>OBJECTIVE</title> This study aimed evaluate...
Abstract Introduction Hyperglycemia is associated with increased morbidity and mortality in critically ill patients strict glycemic control has become standard care for adults. Recent studies have questioned the optimal targets such management reported rates of iatrogenic hypoglycemia both children The ability to provide accurate, real-time continuous glucose monitoring would improve efficacy safety this practice patients. aim our study determine if a continuous, interstitial monitor will...
Abstract Efficient generation of cardiomyocytes from human-induced pluripotent stem cells (hiPSCs) is important for their application in basic and translational studies. Space microgravity can significantly change cell activities function. Previously, we reported upregulation genes associated with cardiac proliferation progenitors derived hiPSCs that were exposed to space 3 days. Here investigated the effect long-term exposure hiPSC-cardiac on global gene expression. Cryopreserved 3D sent...
OBJECTIVE. The initial presentation of congenital and acquired heart disease in children can present a diagnostic challenge. We sought to evaluate B-type natriuretic peptide as marker critical at the acute care setting. METHODS. A cohort 33 pediatric patients with newly diagnosed or had levels obtained on hospital admission after evaluation an Patients were admitted from March 2005 through February 2007. noncardiac 70 who presented respiratory infectious complaints during emergency...
The rapid development of biomedical monitoring technologies has enabled modern intensive care units (ICUs) to gather vast amounts multimodal measurement data about their patients. However, processing large volumes complex in real-time become a big challenge. Together with ICU physicians, we have designed and developed an clinical decision support system icuARM based on associate rule mining (ARM), publicly available research database MIMIC-II (Multi-parameter Intelligent Monitoring Intensive...