A5079552821- Heat shock proteins research
- Skin Protection and Aging
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Anesthesia and Neurotoxicity Research
- thermodynamics and calorimetric analyses
- Renal function and acid-base balance
- Energy, Environment, Economic Growth
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Environmental Impact and Sustainability
- Dermatologic Treatments and Research
- Veterinary medicine and infectious diseases
- Immune cells in cancer
- Intraperitoneal and Appendiceal Malignancies
- Connexins and lens biology
- Receptor Mechanisms and Signaling
- Abdominal Surgery and Complications
- Peptidase Inhibition and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Efficiency Analysis Using DEA
- Advancements in Transdermal Drug Delivery
- Enhanced Recovery After Surgery
- Dietary Effects on Health
Universitat Politècnica de València
2022-2025
CalciMedica (United States)
2014-2016
Allergan (United States)
2016
University of California, San Diego
2006-2011
La Jolla Alcohol Research
2009
Johns Hopkins Medicine
2001-2005
Johns Hopkins University
2001-2005
University of Baltimore
2004
University of Concepción
1998
Abstract Heat shock proteins (hsps) are intracellular chaperones that play a key role in the recovery from stress. Hsp70, major stress-induced hsp, has been found extracellular medium and is capable of activating immune cells. The mechanism involved Hsp70 release controversial because this protein does not present consensual secretory signal. In study, we have shown integrates into artificial lipid bilayer openings ion conductance pathways. addition, was inserted plasma membrane cells after...
The expression of heat shock proteins (HSP) is a conserved cellular response to variety stresses. These have been found refold denatured polypeptides and stabilize critical processes. In this study, we introduce new component the stress response: increase receptor-mediated uptake macromolecules from external environment. We observed that endocytosis transferrin, which involved in delivery iron cell, was increased after induced by or incubation with inhibitors Hsp90 function. both cases,...
Geldanamycin (GA) is an antibiotic produced by Actinomyces, which specifically inhibits the function of heat shock protein 90 family. Treatment a murine macrophage cell line (J774) with GA resulted in reduced response to Escherichia coli lipopolysaccharide (LPS) as visualized decrease NF-kappaB translocation into nucleus and secretion tumor necrosis factor alpha (TNF-alpha). To elucidate mechanism this effect, expression CD14, formal LPS receptor, was analyzed. Cells treated showed level...
Abstract The response to injury is activated at the systemic and cellular levels. At level, phagocytosis plays a key role in controlling infections clearing necrotic apoptotic cells. expression of heat shock proteins (Hsp), which well-conserved process, major component stress. This study investigated relationship between Hsps phagocytosis. An increase opsonized bacteria particles latex beads was observed upon incubation murine macrophages with geldanamycin (GA), specific inhibitor Hsp90...
Summary Background Maintaining a youthful appearance is priority for many people. Global eye rejuvenation sought more frequently and at younger age than other treatments. Major concerns around the area are periorbital hyperpigmentation, puffiness, lines wrinkles. Glycosaminoglycans (GAGs) complex carbohydrates that modulate skin health, repair renew skin's appearance. Heparan sulfate (HS) most biologically active GAG, although it too large polar to penetrate skin. Low Molecular Weight...
Aging is the result of several detrimental changes that lead to a decrease in homeostasis, an increase incidence degenerative diseases, and death. A caloric-restricted diet (CR), which consists significant reduction calorie intake (40%) without malnutrition, has been shown delay onset age-related diseases pathologies extend life span. The aims this study were assess effects aging CR on lipopolysaccharide (LPS)-dependant cytokine production by peritoneal macrophages (PMphis). Resident naïve...
We have shown previously that rats subjected to tourniquet shock develop an acute form of remote organ injury the liver is both Küpffer cell (KC) and polymorphonuclear (PMN) leukocyte dependent. Circulating plasma xanthine oxidase (XO) has been be responsible for development endothelial dysfunction lung intestine after ischemia-reperfusion protocols. now hypothesize XO released from rat hind limbs upon reperfusion it KC PMN activation in this model. Our results show about 30% gastrocnemius...
Diabetes mellitus type 1 (DMT1) is an autoimmune disease characterized by the destruction of insulin-producing cells in pancreas. Diabetic patients are more susceptible to recurrent and uncontrolled infections, with worse prognoses than healthy individuals. Macrophages (MΦs) derived from DMT1 individuals have compromised mounting inflammatory immune responses. The mechanisms responsible for these alterations remain unknown. It has been shown that presence extra- intracellular heat shock...
The role of nitric oxide (NO) on liver oxidative stress and tissue injury in rats subjected to tourniquet shock was investigated. This model differs from others that is a consequence remote organ damage. Liver becomes evident after hind limb reperfusion, as evidenced by the loss total thiols; increases oxidized glutathione (GSSG), lipid peroxidation (LPO), plasma aminotransferases (alanine aminotransferase (ALT) (aspartate (AST)), nitrites; 36% superoxide dismutase (SOD) activity. Portal...
The circular economy (CE) has become key to achieving the environmental objectives set by European Union (EU). This transformative process requires linear production processes be abandoned and replaced with environmentally-friendly models. In this scenario, present study uses Data Envelopment Analysis Sequential Malmquist Index achieve a twofold objective: (1) analyse effectiveness of national CE policies applied 19 EU Member States (2) identify items circularity that need improvement, in...
Aging is a process modulated by multiple factors, including nutrition, social behavior, clinical history, genetics and the environment. It characterized orchestrated changes in an organism's physiology, resulting decreased homeostasis increased incidence of degenerative diseases, with death as final consequence. The mechanisms underlying alterations that occur during aging are not well understood. However, they likely include modulation gene expression, accumulation mutations, decreases...
The mechanisms involved in skin aging are not completely understood, although one of its hallmarks is the reduction epidermal function. Aged-epidermis a constant state water loss, triggering dry skin, flakiness, itchiness, inflammation and increase sensitivity. Cutaneous barrier formation continuous tightly regulated process involving proliferation differentiation. A robust function prevents regulates body temperature, improves host defense protects against environmental stressors....