A5059614624- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- CRISPR and Genetic Engineering
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
Stavanger University Hospital
2021-2024
University of Stavanger
2021-2024
Deaconess Hospital
2023
Haukeland University Hospital
2023
University of Bergen
2023
King's College London
2023
Neuroinflammation contributes to Parkinson disease (PD) pathology, and inflammatory biomarkers may aid in PD diagnosis. Proximity extension assay (PEA) technology is a promising method for multiplex analysis of markers. also plays role related neurodegenerative diseases, such as dementia with Lewy bodies (DLB) Alzheimer (AD). The aim this work was assess the value newly diagnosed patients DLB AD.Patients from Norwegian ParkWest Dementia Study Western Norway longitudinal cohorts (PD, n = 120;...
Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on clinical presentation and progression in a large cohort population-based patients with incident PD. Methods: Four hundred thirty-three 417 controls from three longitudinal cohorts were included study. Disease was recorded annually up to 9 years using Unified Rating Scale (UPDRS) or Mini-Mental State Examination. Genotypes five variants within locus (rs2870004,...
Neurofilament light chain (NFL) is elevated in neurodegenerative diseases, including Parkinson's disease (PD). This study aimed to investigate serum NFL newly diagnosed PD and its association with cognitive motor decline over 10 years. Serum levels were measured patients controls from the ParkWest at diagnosis (baseline) after 3 5 Mixed-effects regression analyzed changes annual MMSE UPDRS-III scores had all visits a faster increase years compared (0.09 pg/mL per year; p = 0.029). Higher...