A5103162659- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurological Complications and Syndromes
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Transplantation: Methods and Outcomes
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Growth Hormone and Insulin-like Growth Factors
- Neonatal Health and Biochemistry
- Infectious Disease Case Reports and Treatments
- Diabetes Treatment and Management
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Complement system in diseases
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2018-2025
Hospital Clínico San Carlos
2008-2023
Universidad Complutense de Madrid
2018-2022
Minimization of immunosuppression and administration antiretrovirals have been recommended for kidney transplant recipients (KTRs) with coronavirus disease 2019 (COVID-19). However, outcomes remain poor. Given the likely benefit cyclosporine because its antiviral immunomodulatory effect, we using it as a strategy in KTRs diagnosed severe acute respiratory syndrome 2 (SARS-CoV-2). We studied 29 who were admitted to our institution COVID-19 between March 15and April, 24, 2020. Mycophenolate...
Background: IgG4 is the least immunogenic subclass of IgG. Immunization with mRNA vaccines against SARS-CoV-2, unlike other vaccines, induces an increase in spike protein healthy populations. This study investigated whether immunosuppressive therapy affects immune response, focusing on IgG changes, to four doses vaccine kidney transplant recipients (KTRs). Methods: includes 146 KTRs and 23 dialysis patients (DPs) who received three mRNA-1273 a BNT162b2 booster. We evaluated anti-spike titers...
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) preserve cardiac and renal function by mechanisms that are not completely elucidated. Among other things, SGLT2i promote nutrient-deprivation signalling, which might affect the immune function. As fate of cells is controlled their metabolism, we aimed to study mitochondrial integrity lymphocytes isolated from transplant recipients with type diabetes (T2D) upon therapy instauration six-month follow up. In this real-world pilot study,...
Despite good long-term outcomes of kidney transplants from controlled donation after circulatory death (DCD) donors, there are few uncontrolled DCD (uDCD) programs. This longitudinal study compares for all uDCD (N = 774) and brain (DBD) 613) performed 1996 to 2015 at our center. DBD were divided into those standard-criteria (SCD) 366) expanded-criteria 247) brain-dead donors (ECD). One-, 5-, 10-year graft survival rates 91.7%, 85.7%, 80.6% SCD; 86.0%, 75.8%, 61.4% ECD; 85.1%, 78.1%, 72.2%...
Background. Few studies have described the clinical impact of anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in renal transplant recipients (RTRs) context omicron variant and third vaccine dose. Antibody titer has been tried to relate prediction outcomes related SARS-CoV-2, but it results controversially these populations. Methods. All patients with positive SARS-CoV-2 polymerase chain reaction followed at a RTRs reference center from March 15, 2020, 2022, were...
Immunocompromised patients have an increased risk of developing severe COVID disease, as well a tendency to suboptimal responses vaccines. The objective this study was evaluate the specific cellular and humoral adaptive immune cohort kidney transplant recipients (KTR) after 3 doses mRNA-1273 vaccine determinate main factors involved. Prospective observational in 221 KTR (149 non infected), 55 healthy volunteers (HV) 23 dialysis (DP). We evaluated anti-spike (by quantitative chemiluminescence...
Emphysematous pyelonephritis (EPN) is a rare and serious necrotizing infection that potentially life-threatening. It has been seldom reported in kidney grafts usually caused by Gram-negative bacteria, with some case reports anaerobic closely associated poorly controlled diabetes mellitus (DM) urinary tract structural abnormalities. There are no of EPN fungal etiology grafts. We present 53-year-old transplant recipient history DM, active vesicoureteral reflux, recurrent infections who...
The incidence of cytomegalovirus (CMV) infection in solid organ transplant recipients may be reduced by antiviral prophylaxis, but this strategy lead to delayed-onset CMV infection. proinflammatory cytokine interleukin (IL)-18 plays a major role viral host defense responses. This study examines the impacts 2 single-nucleotide polymorphisms (SNPs) promoter region IL-18 gene, -607C/A (rs1946518) and -137G/C (rs187238), on patients undergoing kidney transplant.This retrospective analyzed SNPs...
The +874 A/T polymorphism in the interferon gamma (IFNG) gene has been associated with Cytomegalovirus (CMV) infection risk lung and kidney transplant recipients. To replicate this association, we performed a retrospective observational study of immunosuppression therapies considering prophylactic treatment 600 consecutive transplanted We found no association aforementioned CMV univariate multivariate analyses regardless treatment. However, immunosuppressive mammalian target rapamycin...
The genes CD28 , CD86 and CTLA-4 conform the costimulatory (CD28-CD86) or inhibitory (CTLA-4-CD86) signal in T-cell activation. immune response has a critical role allograft rejection, single nucleotide polymorphisms (SNPs) located these have been widely analyzed with controversial results. We group of SNPs three genes: : rs3116496; rs1129055; rs231775 rs3087243 cohort 632 consecutively recruited kidney transplanted subjects. All were genotyped by TaqMan chemistry diagnosis rejection was...
Introduction Although surgical techniques and immunosuppressive treatments have greatly advanced in kidney transplantation, the impact on long-term allograft survival has been limited. Nowadays, no biochemical or immunological markers exist with a high degree of predictive power to detect post-transplant complications. Obviously, earlier detection identification all factors could help us reach better understanding renal graft status efficient implementation noninvasive biomarkers should be...
Background: Cytokines act as immunomodulatory mediators in the alloimmune response and therefore are important factors allograft outcome. A large amount of evidences have shown that genetic control cytokine plasma levels often influenced by single nucleotide polymorphisms (SNP). Obviously, genotypes associated with high expression anti-inflammatory cytokines would be useful for graft survival. Our purpose was to analyze effect some located promoter region IL10 gene related acute rejection...
Sanchez-Fructuoso, A2; Perez-Flores, I1; Calvo, N3; Moreno de la Higuera, M A.4; Giorgi, M5; Anaya, S6; Barrientos, A7 Author Information
Objectives 1) To investigate the risk factors for development of polyomavirus BK infection (BKI). 2) Evaluate impact same on graft survival and renal function at one year. Methods We included 692 consecutive patients who received a kidney transplant in our unit during 2005-2015. Demographic data, pretransplant comorbidity, IC (leukocytes, lymphocytes, CD4, CD8 CD4 / ratio), [creatinine, glomerular filtration rate (GFR) by Cockroft-Gault proteinuria], dose type immunosuppression 1 were...
Introduction Frequently, the use of mycophenolic acid (MPA) meets limited by its regular digestive tolerance and serious infections. The MPAG is a molecule proceeding from metabolism MPA that excreted in biliary route across carrier MRP2, essential entero-hepatic circulation. There controversy over pharmacokinetic clinical impact could suppose polymorphism MRP2 24 C>T renal transplant recipients (RTR) on treatment with MPA. Objectives a) Principal: to investigate if MRP2C-24T determines...
Introduction Frequently, the use of mycophenolic acid (MPA) meets limited by its regular digestive tolerance and serious infections. The MPAG is a molecule proceeding from metabolism MPA that excreted in biliary route across carrier MRP2, essential entero-hepatic circulation. There controversy over pharmacokinetic clinical impact could suppose polymorphism MRP2 24 C>T renal transplant recipients (RTR) on treatment with MPA. Objectives a) Principal: to investigate if MRP2C-24T determines...
Introduction The specific mechanism that can explain the linking of Citomegalovirus (CMV) infection with diminished graft function is not totally clear due to there are numerous issues involved. Some cytokines antiviral proprieties such as interferon gamma (IFN-γ) have been studied. In fact, SNP +874 A/T IFN-γ gene, which linked their levels, has associated increased risk CMV in both lung and kidney transplant recipients. Our purpose was replicate association this SNPin an independent...