A5042064455- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA regulation and disease
- Cancer-related gene regulation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Synthesis and Biological Activity
- interferon and immune responses
- Bioactive Compounds and Antitumor Agents
- RNA and protein synthesis mechanisms
- Papaya Research and Applications
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
Shandong First Medical University
2022-2024
Shandong Tumor Hospital
2022-2024
Baoji University of Arts and Sciences
2022
Xi'an Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Gastric cancer remains the leading cause of death in world. It is increasingly evident that long non-coding RNAs (lncRNAs) transcribed from genome-wide association studies (GWAS)-identified gastric risk loci act as a key mode development and disease progression. However, biological significance lncRNAs at most remain poorly understood.The functions LINC00240 were investigated through series biochemical assays. Clinical implications examined tissues patients.In present study, we identified...
Cinobufacin injection, also known as huachansu, is a preparation form of Cinobufacini made from extract liquid. Despite that injection shown to shrink liver and gastric tumors, improving patient survival life quality, the effective components in remain elusive. In this study, we aim screen antitumor elucidate most for treatment cancers.High performance liquid chromatography (HPLC) LC-MS/MS analysis were used separate determine injection. Inhibition rates various on cancer cells determined...
Alternative polyadenylation (APA) plays a major role in controlling transcriptome diversity and therapeutic resistance of cancers. However, long non-coding RNAs (lncRNAs) involved pathological APA remain poorly defined. Here, we functionally characterize LINC00921, MED13L/P300-induced oncogenic lncRNA, show that it is required for global regulation non-small cell lung cancer (NSCLC). LINC00921 shows significant potential reducing NSCLC radiosensitivity, high levels are associated with poor...
Accumulating evidence has shown that circular RNAs (circRNAs) serve a critical regulatory role in various human cancers, including gastric cancer (GC), and this study, we aimed to explore the functions of circKIF4A progression GC. Our findings demonstrated was highly expressed both GC tissues cell lines, high intratumoral expression predicted poor prognosis patients. In vitro gain- loss-of-function assays indicated knockdown suppressed proliferation, migration, invasion, EMT cells, while...
Papillary thyroid cancer (PTC) is one of the histological subtypes which most common endocrine malignancy in world. The disrupted balance adenosine-to-inosine (A-to-I) RNA editing due to dysregulation genes exists cancer. However, it still largely unknown how functional single-nucleotide polymorphisms (SNPs) A-to-I contribute PTC genetic susceptibility. In this study, we systematically annotated and investigated role 28 potential SNPs ADAR, ADARB1, ADARB2 AIMP2 PTC. We identified rs904957...
Introduction: Transarterial chemoembolization (TACE) is the commonly used therapy of unresectable hepatocellular carcinoma (HCC), though prognosis different TACE-treated HCC patients varies, which may be due to heterogeneity tumors caused by genetic variants and epigenetic changes such as RNA editing. There dysregulated adenosine-to-inosine (A-to-I) editing in RNA-edited genes are involved process. It remains unclear how affect cases treated TACE. Methods: In this study, we examined 28...