A5061743403- Chemokine receptors and signaling
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug Transport and Resistance Mechanisms
- Legionella and Acanthamoeba research
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Sports Performance and Training
- Heme Oxygenase-1 and Carbon Monoxide
- Peptidase Inhibition and Analysis
- Chromosomal and Genetic Variations
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- TGF-β signaling in diseases
- Physics and Engineering Research Articles
- Bone health and osteoporosis research
- Telomeres, Telomerase, and Senescence
- Terahertz technology and applications
- Cardiovascular Effects of Exercise
- Bone Metabolism and Diseases
- Interpreting and Communication in Healthcare
University of Maine
2018-2025
MaineHealth
2022-2025
Northern Illinois University
2021-2025
University of Exeter
2023-2024
Maine Medical Center
2019-2022
Tufts University
2015-2021
Maine Medical Center Research Institute
2019-2021
University of Vermont
2021
Florida Gulf Coast University
2017
UPMC Hillman Cancer Center
2017
Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate. There critical need to find new multiple vulnerabilities and therapeutic avenues. Herein, we identified explored novel target: the fatty acid binding protein (FABP) family. In our work, cells were treated FABP inhibitors (BMS3094013 SBFI-26) examined in vivo vitro for cycle state, proliferation, apoptosis, mitochondrial membrane potential, cellular metabolism (oxygen consumption rates oxidation),...
Abstract Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, adipose tissue (BMAT) expands with aging obesity, two key risk factors multiple myeloma disease prevalence, suggesting that BMAds may influence be influenced by cells the marrow. Here, we provide evidence reciprocal interactions cross-regulation of play a role pathogenesis treatment response. biopsies from patients...
Within the bone marrow microenvironment, mesenchymal stromal cells (MSCs) are an essential precursor to adipocytes and osteoblasts. The balance between this progenitor pool mature (adipocytes osteoblasts) is often skewed by disease aging. In multiple myeloma (MM), a cancer of plasma cell that predominantly grows within marrow, as well other cancers, MSCs, preadipocytes, have been shown directly support tumor survival proliferation. Increasing evidence supports idea MM-associated MSCs...
Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate 59%. Dysregulation fatty acid (FA) metabolism associated MM development and progression; however, the underlying mechanisms remain unclear. Herein, we explore roles long‐chain coenzyme A ligase (ACSL) family members in MM. ACSLs convert free acids into acyl‐CoA esters play key catabolic anabolic metabolism. Analysis Myeloma Research Foundation (MMRF) CoMMpass SM study showed that high ACSL1 ACSL4...
ABSTRACT Intracellular growth of Legionella pneumophila occurs in a replication vacuole constructed by host proteins that regulate vesicular traffic from the endoplasmic reticulum (ER). This process is promoted combination approximately 300 Icm/Dot translocated substrates (IDTS). One these proteins, Ceg9, was previously identified screen for L. IDTS manipulate secretory when overexpressed yeast. Using ectopic expression Ceg9 mammalian cells, we demonstrate interacts with isoforms reticulon 4...
Abstract Adipose tissue is a vital in mammals that functions to insulate our bodies, regulate internal thermostat, protect organs, store energy (and burn energy, the case of beige and brown fat), provide endocrine signals other organs body. Tissue engineering adipose soft tissues may prove essential for people who have lost this from trauma or disease. In review, we discuss applications tissue-engineered specifically disease modeling applications. We basic background depots describe...
New Zealand blackcurrant (NZBC) extract increased 16.1 km cycling time trial performance. The aim of the present study was to examine effect NZBC on 2 × 4 Ten male cyclists (age: 30 ± 12 years, body mass: 74 9 kg, height: 179 7 cm, fat: 11 3%, (V̇) ̇O2max: 55 mL•kg−1•min−1, mean SD) volunteered. Participants were familiarized with trials. consumed capsulated (300 mg∙day−1 CurraNZ™; containing 105 mg anthocyanin) or placebo for seven days (double blind, randomised, cross-over design, wash-out...
ABSTRACT Legionella pneumophila grows within cells ranging from environmental amoebae to human macrophages. In spite of this conserved strategy pathogenesis, identification host factors that restrict L. intracellular replication has not been extended outside components the mammalian innate immune response. We performed a double-stranded RNA (dsRNA) screen against more than 50% Drosophila melanogaster annotated open reading frames (ORFs) identify cell . The majority analyzed dsRNAs stimulated...
Significance The host cell cycle regulatory proteins control Legionella pneumophila growth. In particular, bacterial replication is depressed in S phase. This indicates that of the can limit exposure pathogen to antimicrobial events are cycle-specific. Here we uncovered factors induce arrest by inhibiting protein synthesis and preventing S-phase transition. These data consistent with toxicity serving as an important response limits growth some intracellular pathogens. Moreover,...
Transforming growth factor β1 (TGF-β1) is the prototype of a large family factors involved in cell control, development, angiogenesis, and wound healing (for review, see Barnard et al. 1990). This polypeptide displays wide array biological activities that vary depending on type involved. TGF-β1 stimulates extracellular matrix formation fibroblast migration vitro, events critical for (Moses 1985; Shipley Ignotz Massagué 1986; 1987; Raghow 1987). Stimulation appears to be indirect, mediated...
ABSTRACT Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5-year survival rate 59%. Dysregulation fatty acid (FA) metabolism associated MM development and progression; however, the underlying mechanisms remain unclear. Acyl-CoA synthetase long-chain family members (ACSLs) convert free acids into acyl-CoA esters play key roles in catabolic anabolic metabolism. The Cancer Dependency Map data suggested that ACSL3 ACSL4 were among top 25% Hallmark Fatty Acid Metabolism genes...
Measurement of telomere length by fluorescent in situ hybridization is widely used for biomedical and epidemiological research, but there has been relatively little development the technology 20 years since it was first reported. This report describes use dual gammaPNA (γPNA) probes that hybridize at alternating sites along a give rise to Förster resonance energy transfer (FRET) signals. Bright staining telomeres observed nuclei, chromosome spreads tissue samples. The FRET detection also...
Bottom-up self-assembly of components, inspired by hierarchically self-regulating aggregation small subunits observed in nature, provides a strategy for constructing two- or three-dimensional intriguing biomimetic materials via the spontaneous combination discrete building blocks. Herein, we report methods ultrasonic wave energy-assisted, fast, and mesoscale well-ordered microfabricated blocks (100 μm size). Mechanical vibration energy-driven microplatelets at water-air interface inverted...
ABSTRACT Background Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate, highlighting critical need for new multiple vulnerabilities and therapeutic avenues. Herein, we explored novel target: the fatty acid binding protein (FABP) family. Methods Myeloma cells treated FABP inhibitors (BMS3094013 SBFI-26) were examined in vivo vitro cycle, proliferation, apoptosis, mitochondrial membrane potential, cellular metabolism (oxygen consumption rates...
Blood flow simulations have important applications in engineering and medicine, requiring visualization analysis for both fluid (blood plasma) solid (cells). Recent advances blood highlight the need of a more efficient large data sets. Traditionally, is performed after simulation completed, any changes settings require running again. With bi-directional situ we aim to solve this problem by allowing manipulation parameters run time. In project, describe our early steps toward goal present...