A5037995958- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
- Shoulder Injury and Treatment
- Cancer Genomics and Diagnostics
- Hip and Femur Fractures
- Hernia repair and management
- Spinal Fractures and Fixation Techniques
- Body Composition Measurement Techniques
- Nerve Injury and Rehabilitation
- Shoulder and Clavicle Injuries
- Renal and related cancers
- Hippo pathway signaling and YAP/TAZ
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Hip disorders and treatments
- Medical Imaging and Analysis
- Musculoskeletal synovial abnormalities and treatments
- Congenital Diaphragmatic Hernia Studies
- Reconstructive Surgery and Microvascular Techniques
- Winter Sports Injuries and Performance
- Cervical and Thoracic Myelopathy
- Lower Extremity Biomechanics and Pathologies
- Sports injuries and prevention
The Ohio State University Wexner Medical Center
2014-2025
The Ohio State University
2018-2024
Massachusetts General Hospital
2016
Harvard University
2016
Columbus State University
2015
Abstract Background Sarcomas constitute a heterogeneous group of tumors with different clinical behaviors and variable responses to systemic therapies. Recent immunotherapy studies PD1 inhibitors (PD1i) show promising results use in certain soft-tissue sarcomas; however, the molecular features that best predict response PD1i remain unclear. Methods Demographic, imaging, histologic, genetic sequencing data was collected for sarcoma patients who received nivolumab or pembrolizumab treatment at...
A posterior rectus sheath hernia is an abdominal wall that rarely encountered. Owing to its rarity, it can be easily overlooked in the setting of a patient presenting with pain. We report case caused intermittent small bowel obstruction. The unusual aspects this are defect was large, measuring 6 cm transverse diameter, and contained within large portion sheath. Because affected nearly entire sheath, difficult discern on computed tomography until obstruction developed. In case, limited...
Soft tissue sarcomas (STS) are diverse tumors with heterogenous alterations. Platforms to detect circulating tumor DNA (ctDNA) have rapidly increased in popularity as they may avoid invasive biopsy morbidity. However, ctDNA profiling concordance standard solid comprehensive genomic (CGP) is poorly characterized. Here, we report the outcomes of a single-institution experience comparing mutational results from commercial and CGP advanced STS subjects. We identified subjects who had undergone...
Retrospective cohort study.To study the impact of smoking on patient-reported outcomes after primary 2-level anterior cervical discectomy and fusion (ACDF).Previous studies have found suboptimal multilevel ACDF in patients. There is contrasting evidence negative effects single-level ACDF, while there are no specific reports ACDF. Adding knowledge smoking's (PRO) will help tailored patient counseling preoperative education.Patients 18 years age or older at a single academic institution who...
Despite immunotherapy's promise in oncology, its use for sarcoma remains challenging. There are no sarcoma-specific biomarkers immune checkpoint inhibitors (ICI). Previously, we reported our institutional experience highlighting ICI activity 29 patients with sarcoma. In this study, explore responses to based on regimen and other covariates identify significant clinical factors advanced outcomes.Patients The Ohio State University Sarcoma Clinics were enrolled the Retrospective database from...
e23541 Background: Sarcomas constitute a heterogeneous group of mesenchymal tumors with variable responses to traditional chemotherapies. Recent PD-1i immunotherapy studies show promising results use in certain soft-tissue sarcomas, however, clinical and molecular features which best predict response are unclear. In this study, we explore PD1i cohort patients treated off-trial as stratified by tumor patient demographics. Methods: Demographic, imaging, histologic, genetic sequencing data was...