A5058087439- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Machine Learning in Bioinformatics
- interferon and immune responses
Vavilov Institute of General Genetics
2024
State Research Institute of Highly Pure Biopreparations
2018
City Clinical Oncology Center
2014-2018
Peter the Great St. Petersburg Polytechnic University
2018
Human gene LOC100505644 uncharacterized [Homo sapiens] (Entrez Gene ID 100505644) is abundantly expressed in tumors but weakly few normal tissues. Till now the function of this remains unknown. Here we identified chromosomal borders transcribed region and major splice form LOC100505644-specific transcript. We characterised regulatory motifs its sites. Analysis secondary structure transcript variant revealed a hairpin-like characteristic for precursor microRNAs. Comparative genomic analysis...
The orthopedia homeobox (OTP) gene encodes a homeodomain-containing transcription factor involved in brain development. OTP is mapped to human chromosome 5q14.1. Earlier we described the second intron of this wide variety tumors, but among normal tissues only testis. In GeneBank these transcripts are represented by several 300–400 nucleotide long AI267901-like ESTs. We assumed that ESTs belonged longer transcript(s). used Rapid Amplification cDNA Ends (RACE) approach and other methods find...
Abstract Transcribed locus Hs.633957 had been previously shown to be over-expressed in various tumors, but its function remained unknown. We conducted a combined experimental and bioinformatical analysis of the get an insight into function. used RACE (Rapid Amplification cDNA Ends) define boundaries transcribed part RT-PCR identify splice-forms. analyzed public data on chromatin modifications association with transcription factors available at UCSC Genome Browser modeled RNA secondary...
Abstract Orthopedia homeobox ( OTP ) gene encodes a homeodomain-containing transcription factor involved in brain development. is mapped to human chromosome 5q14.1. Earlier we described the second intron of this wide variety tumors, but among normal tissues only testis. In GeneBank these transcripts are presented by several 300-400 nucleotides long AI267901-like ESTs. We assumed that ESTs belong longer transcript(s). used Rapid Amplification cDNA Ends (RACE) approach and other methods find...