Under physiological conditions, blood volume and extracellular are in a ratio of 1-3, even hemodialysis patients. The question therefore arises: can be inferred from the bioimpedance analysis data? aim study was to compare volumes calculated determined by data actually measured volumes. Immediately before treatment, overload were evaluated spectroscopy. actual indicator dilution, using an on-line infusate bolus subsequent calculation with relative monitor. Alternatively, divided 3 compared...

Background: We developed a simple method to determine the absolute blood volume (V) during hemodialysis in everyday clinical practice and examined its relationship with overload, relevance, accuracy. Methods: The increase relative (RBVpost - RBVpre) measured before after infusion of 240 ml ultra-pure dialysate using bolus function commercial online hemodiafiltration machine incorporating monitor was applied volume. specific (Vs, per kg body mass at dry weight, ml/kg) compared status as...

The reduction of blood volume below a critical threshold is assumed to trigger intradialytic morbid events (IME). Recently, we presented simple method determine the absolute during routine hemodialysis (HD) carried out without sampling and injection dyes or radiolabeled markers. Such information could be used detect excessive HD prevent IME. Therefore, performed pilot study in IME-prone patients identify at which they developed clinical symptoms. A 240 mL ultrapure dialysate was...

Background.The outcome of patients with septic multiple organ failure (MOF) remains poor. There are experimental and clinical data indicating a beneficial effect high-volume haemofiltration. Delivering therapy is only cost effective using on-line devices because high costs for additional solution bags in conventional continuous renal replacement (CRRT). We investigated feasibility effectiveness extended daily haemodiafiltration (HDF) technically maximum convective volume MOF pilot study.

It was the aim to measure distribution volume and elimination of ultra-pure dialysate in stable hemodialysis patients during on-line hemodiafiltration (HDF). Dialysate automatically infused as a indicator using standard HDF equipment. Indicator concentration noninvasively measured arterial blood-line (using blood monitor, Fresenius Medical Care, Bad Homburg vor der Höhe, Germany), its time course analyzed obtain rate V(t) at dilution. Blood treatment start (V0) calculated accounting for...

Abstract Introduction Blood volume changes and vascular refilling during hemodialysis (HD) ultrafiltration (UF) have been assumed to depend on overload ( V o ). It was the aim study magnitude of in stable HD patients with moderate expansion everyday dialysis using novel technical approaches. Methods Patients were studied routine UF based clinical dry weight assessment. Pre‐dialysis independently measured by bioimpedance spectroscopy. Vascular ref ) calculated as: = uf − ΔV , where is...

Adequate volume management removing excess and at the same time avoiding intradialytic morbid events (IME) remains a core problem in current hemodialysis (HD) therapy. Recently, we developed feasible method to determine absolute blood (Vs, mL/kg) patients on HD. The aim of this study was investigate suitability Vs measurements for management.Following 4 week baseline phase quantify frequency IME, status determined single specified HD session during which measured using dialysate dilution,...

Abstract Introduction The success of automatic feedback control systems to improve hemodynamic stability by preventing relative blood volume from dropping beyond a critical value during dialysis is limited. aim this study was use one these for absolute rather than prevent volume‐dependent morbid events. Methods Dialysis delivered machine providing ultrafiltration rates, monitoring, and accurate bolus infusion 240 mL dialysate measure at the beginning dialysis. Critical required algorithm...

<b><i>Background:</i></b> In Germany, every fifth patient starting dialysis is now 80 years of age or older. The question that currently relevant not whether we have to treat patients who are older than 80. Rather the how this elderly group patients. <b><i>Methods:</i></b> Single centre data all aged over were analyzed with regard survival, social circumstances, vascular access, and pre-dialysis nephrology care....

Current online hemodiafiltration devices can be used to determine the absolute blood volume in clinical practice using dialysate bolus method. Most of publications on this method have focused preventing intradialytic complications. The influence long-term prognosis has not been reported yet. A total 79 participants a previous study about were followed for 5 years. Patients with specific above (

Recording the relative blood volume is a standard feature of modern dialysis devices, enabling feedback guidance ultrafiltration and dialysate conductivity. Technically, process based on optical or ultrasonic methods. On grounds clinical evidence suggesting malfunction hemoglobin (Hb)-dependent absorbance method in presence sodium changes, we compared system with method. Six patients underwent hemodialysis step profile (140, 150, 130, 140 mmol/L, hourly switch), two devices featuring...

<b><i>Background:</i></b> Volume management during renal replacement therapy (RRT) in septic shock is always the conflict between aggravating hypovolemia by undue ultrafiltration (UF) and insufficient reduction of fluid overload which associated with adverse outcome. Relative blood volume (RBV) monitoring could be helpful for timely transition from resuscitation to removal. <b><i>Methods:</i></b> Data RBV were continuously monitored used...

It is commonly believed that insufficient vascular refilling leads to hypovolemia during hemodialysis and contributes intradialytic morbid events (IME). But data of volumes at the time IME are lacking.We compared in 10 patients with 14 stable normal blood volume dialysis end (66-80 mL/kg).The characteristics did not differ from those patients. The fraction (refilling/ultrafiltration [UF] ratio) was 73.8 ± 9.4% IME, 70.2 6.4% treatment. Refilling strongly correlated UF both patient groups (r2...

Recording the relative blood volume is a standard feature of modern dialysis devices. Three different measurement systems are incorporated in currently available machines. The Gambro-Hospal group and Nikkiso monitors based on optical methods. Fresenius Medical Care machines perform monitoring with an ultrasonic method. On grounds clinical evidence suggesting malfunction methods presence sodium changes, we compared these three systems. Under tested conditions, both show opposite nonplausible...

Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultrapure dialysate into extracorporeal circulation can be used determine absolute in clinical practice. The aim present study was evaluate reproducibility such measurements. Intra-individual evaluated four measurements taken hourly intervals within same dialysis treatment. Ten patients were studied. Absolute volumes measured at beginning after 1 hour significantly...

The ratio of blood volume to extracellular is approximately one three under physiological conditions and also in stable chronic hemodialysis patients. Recently, it was found that this remains unchanged during despite ultrafiltration. This would signify the higher ratio, lower refilling vice versa. To test hypothesis, treatment data a previous study were re-analyzed. In 79 patients, fraction 0.749 ± 0.094. There significant negative correlation (r = -0.412; p < 0.001) between fraction....

Long dialysis treatments are generally assumed to mitigate the ultrafiltration (UF) induced volume perturbation and improve vascular refilling because of reduced UF rates sufficient time for re-equilibration. The course was therefore examined during extended nocturnal dialysis.For each hour dialysis, calculated from absolute blood changes removed. Absolute estimated by indicator dilution at beginning then tracked with a relative monitor. fraction defined as ratio volume.Ten stable chronic...

Absolute blood volume can be calculated from the increase in relative after an infusion of a well-defined bolus ultrapure dialysate into extracorporeal circulation. Several working groups have applied this method research and clinical practice. A critical analysis differing data between revealed methodologic problems measurement procedure some important technical aspects. This paper presents statement to standardize method.

The rate and the duration of ultrafiltration (UF) are considered most important factors to affect vascular refilling. aim study was investigate whether a UF profile could improve