A5075813861- Respiratory viral infections research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Respiratory and Cough-Related Research
- Animal Disease Management and Epidemiology
- Gut microbiota and health
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Indoor Air Quality and Microbial Exposure
- Nutrition, Health and Food Behavior
- Exercise and Physiological Responses
- RNA modifications and cancer
- Primate Behavior and Ecology
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Phytoestrogen effects and research
- Odor and Emission Control Technologies
- Zoonotic diseases and public health
- Virology and Viral Diseases
- Probiotics and Fermented Foods
University of Wisconsin–Madison
2007-2024
Harvard University Press
2017
University of New Mexico
2017
Makerere University
2017
Tufts University
2017
Animal Welfare Institute
2017
UW Health University Hospital
2012
To test the hypothesis that rhinovirus (RV)-induced immune responses influence outcome of RV infections, we inoculated 22 subjects with allergic rhinitis or asthma RV16. Nasal secretions and induced sputum were repeatedly sampled over next 14 d. RV16 infection increased nasal granulocyte colony-stimulating factor (G-CSF) interleukin (IL)-8, which was accompanied by neutrophilia in blood secretions. G-CSF correlated closely neutrophils (rs = 0.69, p < 0.005), whereas both 0.87, 0.001) IL-8...
Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks two distinct respiratory viruses, metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and respirovirus 3 (HRV3; Paramyxoviridae; Respirovirus, formerly known as parainfluenza virus 3), in chimpanzee (Pan troglodytes schweinfurthii) communities the same forest Uganda December 2016 January 2017. The were absent before outbreaks, but each was present ill chimpanzees...
We describe a lethal respiratory outbreak among wild chimpanzees in Uganda 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout tract; other pathogens were absent. Epidemiologic modeling estimated basic reproductive number (R0) epidemic 1.83, consistent with common cold humans. Genotyping of 41 examination 24 published genomes subspecies across Africa...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Human rhinoviruses (RVs), comprising three species (A, B, and C) of the genus Enterovirus, are responsible for majority upper respiratory tract infections associated with severe lower illnesses such as pneumonia asthma exacerbations. High genetic diversity continuous identification new types necessitate regular updating diagnostic assays accurate comprehensive detection circulating RVs. Methods molecular typing based on phylogenetic comparisons a variable fragment in 5' untranslated region...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Viral infection is a major cause of ill health in wild chimpanzees (Pan troglodytes), but most evidence to date has come from conspicuous disease outbreaks with high morbidity and mortality. To examine the relationship between viral during periods not associated outbreaks, we conducted longitudinal study eastern (P. t. schweinfurthii) Kanyawara Ngogo communities Kibale National Park, Uganda. We collected standardized, observational data for 4 years then used metagenomics characterize...
Abstract Background Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects cryopreservation on cytokine responses are incompletely understood. In designing studies a new birth cohort study childhood asthma, we performed series experiments determine the two different methods cord cells. Results Paired samples PBMC were processed freshly, or after in Nalgene container (NC)...
RATIONALE: In infancy, rhinovirus illnesses and severe RSV bronchiolitis indicate increased risk for recurrent wheezing asthma, but there is less information about other viruses. We evaluated the frequency severity of metapneumovirus (HMPV) coronavirus (HCV) infections in a high-risk group infants. METHODS: Nasal lavage samples were obtained first year life during scheduled study visits symptomatic respiratory as part Childhood Origins Asthma Project (COAST). Samples (n = 567) analyzed by...