A5009755188- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- HIV/AIDS drug development and treatment
- Oral and Craniofacial Lesions
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemotherapy-induced organ toxicity mitigation
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
Centro Hospitalar do Porto
2017-2021
CUF Porto Hospital
2021
IPO Porto
2019
Instituto Português de Oncologia Francisco Gentil
2019
Multiple myeloma (MM) accounts for 1% of all cancers. It consists malignant proliferation plasma cells, which is often associated with hypersecretion a monoclonal protein. Pleural effusion (PE) in MM not an uncommon finding, comprising about 6‑14% patients MM. The most common causes MM‑associated PE are congestive heart failure, renal parapneumonic and amyloidosis. In <1% cases, the direct result MM, designated as myelomatous (MPE). MPE usually diagnosis exclusion carries poor prognosis....
A 69-year-old caucasian man, ECOG-1, was diagnosed with IgA/lambda and lambda free light chains multiple myeloma (MM), stage IIIB, ISS-2/3, presenting anemia, lytic bone lesions, hypercalcemia, renal failure on dialysis. He initiated treatment bortezomib, dexamethasone (VD), epoetin, zolendronic acid. Once creatinine recovered, thalidomide added (VTD). completed five cycles, obtaining partial response. Not being candidate for autologous transplant, he started maintenance therapy (TalDex)....
A 40-year-old postpartum woman presented with marked bilateral enlargement of the breasts (left), constitutional symptoms and cervical lymphadenopathy, which had first appeared a month previously. Laboratory tests showed anaemia (haemoglobin concentration 97 g/l), thrombocytopenia (platelet count 33 × 109/l) high levels serum lactate dehydrogenase, total bilirubin aspartate aminotransferase; other liver enzymes were within normal limits. peripheral blood film was leucoerythroblastic...
Background: Inherited Bone Marrow Failure Syndromes (IBMFS) are rare, heterogeneous disorders characterized by multiorgan disease, congenital malformations, high risk of solid tumors and hematopoietic impairment with predisposition to clonal evolution secondary Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). The four most frequent syndromes Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond Blackfan (DBA) Shwachman syndrome (SDS). Allogeneic cell transplantation...
Autoimmune cytopenia, a known paraneoplastic complication of lymphoid neoplasms, may occur before, concurrently, at relapse, or even years after completion lymphoma treatment. In the case Hodgkin (HL), it is thought that immune dysregulation, typical this neoplasm, be involved in genesis these manifestations. We report 57-year-old male presenting with stage IIIA, International Prognostic Score (IPS) 4, nodular sclerosis HL, and severe AA (SAA) confirmed on histologic exam bone marrow showed...
Introduction: Relapse/refractoriness (R/R) in diffuse large B cell (DLBCL) and high grade (HGL) lymphomas affects more than 1/3 of the patients, constituting an unfavorable prognosis therapeutic challenge. Methods: This single-center retrospective analysis aims to describe response 1st line salvage treatment patients with DLBCL HGL diagnosed between 2015-2019. Results: 125 were diagnosed. Of these, 58 did not undergo curative chemoimmunotherapy (R-ChT) (median age 76 years; ECOG ≥2 40%). We...