The identification of new genes that are mutated in osteosarcomas is critical to developing a better understanding the molecular pathogenesis this disease and discovering targets for therapeutic development.The authors identified somatic nonsynonymous coding mutations oncogenes associated with human cancers hotspot from tumor suppressor were either well described literature or observed multiple times cancer sequencing efforts. Then, 961 89 systematically characterized across 98 osteosarcoma...

Sunitinib is a tyrosine kinase/angiogenesis inhibitor with proven efficacy in gastrointestinal stromal tumor and advanced renal cell carcinoma. We are presenting the case report of patient aggressive alveolar soft part sarcoma lung bone metastases, who had failed multiple chemotherapy regimens showing significant response to sunitinib. There was not only complete regression primary tumor, stabilization his metastases improvement quality life. Our shows that sunitinib has capability playing...

Management of soft tissue sarcomas can be very challenging because they have a high rate metastasis, especially to the lungs, and respond poorly currently available chemotherapeutic drugs. We present case epithelioid sarcoma in which complete remission pulmonary metastases was observed after treatment with single agent, navelbine, vinca alkaloid, potential therapeutic agent. The patient has been persistently free for 4 years since navelbine. Further studies are warranted establish role...

1Home Stryker School of Medicine, Bronson Cancer Care Center, Battle Creek, MI 2Bronson The authors have no conflicts interest to declare.

Bortezomib with or without dexamethasone has been reported to be very effective and well tolerated in the treatment of AL amyloidosis. Commonly adverse effects are fatigue, nausea, vomiting, diarrhea, constipation, postural hypotension from autonomic neuropathy, peripheral thrombocytopenia anemia. Dyspnea rarely as an effect bortezomib therapy We reporting three case reports patients suffering amyloidodis, who had new onset acute dyspnea secondary that required drug discontinuation. There...

Gastrointestinal stromal tumors (GISTs) are the most common nonepithelial of gastrointestinal tract characterized by mutations activating c-KIT or platelet-derived growth factor receptor alpha. GISTs frequently metastasize to liver and peritoneum, but rarely bones. Imatinib, a tyrosine kinase inhibitor, has revolutionized treatment advanced metastasized both slowing down disease progression prolonging survival. Occasionally, patients with can develop primary secondary resistance imatinib...

Primary renal extraskeletal Ewing sarcoma (EES) is rare but well known to be aggressive, less responsive the treatment, and has early predilection for metastases. Metastases at time of diagnosis lungs or bones are associated with poor outcome. We present a case primary EES in 57-year-old woman multiple metastases complete remission disease last 8 years following multimodality treatment Multidisciplinary approach management definitely improved quality life survival patients.

Background Lung cancer is the most frequent cause of cancer-related deaths and common type globally. It generally classified into two main histologic subtypes: non-small cell lung (NSCLC) small (SCLC). NSCLC prevalent enriched with genetic molecular diversity. This study evaluated clinical, molecular, demographic characteristics patients NSCLC, a focus on variables involving disease stage, survival rates, mutations in epidermal growth factor receptor (EGFR) anaplastic lymphoma kinase (ALK)...

1Homer Stryker School of Medicine, Bronson Cancer Care Center, Battle Creek, MI 2Department The authors have no conflicts interest to declare.

Purpose: We report a case of 52-year-old female who presented with 3-week history worsening, continuous left upper quadrant pain radiation to the back, associated decreased appetite, weight loss, and low grade fever. Blood work revealed elevated lipase level up 2,354 U/L. CT scan abdomen large mass in head pancreas intrahepatic biliary tree dilatation multiple hepatic lesions. Endoscopic evaluation showed high-grade ulcerated stricture at duodenal sweep. Biopsies were obtained from...

Purpose: Muir-Torre syndrome (MTS) is a rare autosomal dominant familial cancer diagnosed with occurrence of cutaneous sebaceous tumors along at least one visceral malignancy, most frequently gastrointestinal carcinoma. We report case 46-year-old man who was Stage II B colorectal in 2002 treated partial colonic resection. Surveillance colonoscopy 2005 revealed tubular adenoma which resected endoscopically. His father colon the age 42 and pancreatic 62. Paternal uncle had 56 paternal...

Purpose: A 48-year-old male on coumadin for history of CVA in the past presented to emergency department from a nursing home lower GI bleed. Along with this patient also complained left-sided abdominal pain. Patient was poor. Past medical significant DM2, cognitive deficits secondary brain injury, alcohol abuse, hypothyroidism, schizophrenia and pancreatitis as per chart. On admission awake, alert responsive, his initial blood pressure 70/47 mm Hg, pulse 131 beats minute, respirations were...