A5026824077- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Bone and Dental Protein Studies
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Signaling Pathways in Disease
- Bone Tissue Engineering Materials
- Williams Syndrome Research
- Cancer Genomics and Diagnostics
- Studies on Chitinases and Chitosanases
- Cardiac Structural Anomalies and Repair
- Electrospun Nanofibers in Biomedical Applications
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Parathyroid Disorders and Treatments
- Ion Transport and Channel Regulation
Australian Regenerative Medicine Institute
2022
Monash University
2022
Zewail City of Science and Technology
2016-2020
Menoufia University
2017
Qatar University
2015
University of Toledo Medical Center
2013
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy various experimental models. The upregulation NHE1 was correlated with an increase osteopontin (OPN) models cardiac (CH), mechanism for this remains to be delineated. To determine whether active NHE1-induces OPN contributes hypertrophic response vitro, cardiomyocytes were infected form adenovirus or transfected silencing RNA (siRNA-OPN) characterized hypertrophy....
Studies using pharmacological and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in pathogenesis cardiac hypertrophy. Despite importance NHE1 hypertrophy, severe cerebrovascular side effects were associated with use inhibitors when administered to patients myocardial infarctions. p90 ribosomal S6 Kinase (RSK), downstream regulator mitogen-activated protein kinase pathway, has also been implicated We hypothesized...
Abstract Myosin‐binding protein C 3 ( MYBPC3 ) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical heterogeneity. genotype–phenotype associations remain poorly understood. We investigated impact two novel human splice‐site variants: V1 : c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; V2 c.772+1G>A 6 MOe6i6; located within C1 domain cMyBP‐C protein, known be critical in...
Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating key role that cMyBP-C plays heart’s contractile machinery. To investigate c-MYBPC3 HCM-related impairment, we generated a zebrafish mypbc3-knockout model. These knockout displayed significant morphological heart alterations related to decrease ventricular and atrial diameters at systolic diastolic states larval stages. Immunofluorescence staining revealed...
Purpose: Muir-Torre syndrome (MTS) is a rare autosomal dominant familial cancer diagnosed with occurrence of cutaneous sebaceous tumors along at least one visceral malignancy, most frequently gastrointestinal carcinoma. We report case 46-year-old man who was Stage II B colorectal in 2002 treated partial colonic resection. Surveillance colonoscopy 2005 revealed tubular adenoma which resected endoscopically. His father colon the age 42 and pancreatic 62. Paternal uncle had 56 paternal...
The novel space is one of the basic components novel.It internal structures as it a large linguistic structure composed several minor structures.The also sign that helps in reading novel, with its various components, from particular perspective.The Journey Ibn Fattouma by Naguib Mahfouz creative work travel litterature which includes issues life and existence Arabs reality pros cons accompany human time place.The wider more comprehensive perception place reltionship story discourse including...