A5093841542- RNA Research and Splicing
- 3D Printing in Biomedical Research
- Cancer Research and Treatment
- Amyotrophic Lateral Sclerosis Research
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
Weizmann Institute of Science
2024
Loss of nuclear TDP-43 splicing activity is a common feature across neurodegenerative diseases, but its relevance to Alzheimer's disease (AD) remains unclear. Here, we show that pathology in AD broadly associated with abnormalities, including aberrant amyloid precursor protein (APP). We demonstrate drives the formation elongated APP isoforms, APP751 and APP770. Thus, dysregulation disrupts APP695/751/770 alternative ALS/FTLD-TDP AD, providing compelling mechanism for 37-year-old observation...
Abstract Systematic assessment of organelle architectures in cells, known as the organellome, could provide valuable insights into cellular states and disease pathologies but remains largely uncharted. Here, we devised a novel pipeline combining self-supervised deep learning transfer to generate Neuronal Organellomics Vision Atlas (NOVA). Analyzing over 1.5 million confocal images 24 distinct membrane-bound membrane-less organelles human neurons, enable simultaneous evaluation all...