A5051385374- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Viral gastroenteritis research and epidemiology
- Chemical Synthesis and Analysis
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Lipid metabolism and biosynthesis
- Hepatitis B Virus Studies
- Sphingolipid Metabolism and Signaling
- Nanoparticle-Based Drug Delivery
- Hepatitis C virus research
Northeastern University
2021-2025
Universidad del Noreste
2024
Brooklyn College
2018-2020
City University of New York
2018-2020
We performed all-atom and coarse-grained simulations of lipid bilayer mixtures the unsaturated DOPC, with saturated lipids having same 18-carbon acyl tails different headgroups, to understand their mechanical properties. The secondary were DSPG, DSPA, DSPS, DSPC, DSPE. DOPC:DSPG system 65:35 molar ratio was softest, area compressibility modulus KA ∼ 22% smaller than pure DOPC value. Raising mole % leads increases in KA, yet at any given composition trend is DSPG < DSPA DSPS DSPC Lipid-lipid...
Lysophosphatidic acid receptor 1 (LPAR1) is elevated in breast cancer. The deregulation of LPAR1, including the function and level expression, linked to cancer initiation, progression, metastasis. LPAR1 antagonists, AM095 or Ki16425, may be effective therapeutic molecules, yet their limited water solubility hinders vivo delivery. In this study, we report on synthesis two liposomal formulations incorporating embedded within lipid bilayer, as targeted nanocarriers for metastatic (MBC). data...
We performed all-atom and coarse-grained simulations of lipid bilayers mixtures the unsaturated DOPC, with saturated lipids having same 18-carbon acyl tails different headgroups, to understand their mechanical properties. The secondary were DSPG, DSPA, DSPS, DSPC DSPE. DOPC:DSPG system 65:35 molar ratio was softest, area compressibility modulus KA ~22% smaller than pure DOPC value. Raising mole% leads increases in KA, yet at any given composition trend is DSPG < DSPA DSPS Lipid-lipid...