A5039894706- Microbial Fuel Cells and Bioremediation
- Electrochemical sensors and biosensors
- Malaria Research and Control
- Mosquito-borne diseases and control
- Supercapacitor Materials and Fabrication
- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Travel-related health issues
- Historical Economic and Social Studies
- Lipid Membrane Structure and Behavior
- Wastewater Treatment and Nitrogen Removal
- Economic Theory and Institutions
- HIV Research and Treatment
- Water Treatment and Disinfection
- Fecal contamination and water quality
- Plant and Biological Electrophysiology Studies
- Economic Growth and Productivity
- Microbial Metabolic Engineering and Bioproduction
- Lysosomal Storage Disorders Research
- biodegradable polymer synthesis and properties
- Aerospace and Aviation Technology
- Chromium effects and bioremediation
- Bacterial biofilms and quorum sensing
West Chester University
2013-2024
Pennsylvania State University
2012-2018
Johns Hopkins University
2005-2017
University of Maryland, Baltimore
2009-2011
Virginia Tech
2009
Biotechnology Institute
2009
University of Maryland Medical Center
2009
University of South Florida
2002
Background Cyanobacteria account for 20–30% of Earth's primary photosynthetic productivity and convert solar energy into biomass-stored chemical at the rate ∼450 TW [1]. These single-cell microorganisms are resilient predecessors all higher oxygenic phototrophs can be found in self-sustaining, nitrogen-fixing communities world over, from Antarctic glaciers to Sahara desert [2]. Methodology/Principal Findings Here we show that diverse genera cyanobacteria including biofilm-forming pelagic...
The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within acidic digestive vacuole where haemoglobin is degraded. Haem crystallization the target of widely used antimalarial quinoline drugs. mechanism molecular initiation crystallization, whether by proteins, polar membrane lipids or neutral lipids, has not been fully substantiated. In present study, we show lipid predominant nanospheres, which envelop haemozoin inside Plasmodium falciparum...
Abstract The current study introduces an aerobic single‐chamber photosynthetic microbial fuel cell (PMFC). Evaluation of PMFC performance using naturally growing fresh‐water biofilm revealed a weak positive light response, that is, increase in voltage upon illumination. When the anodes were coated with electrically conductive polymers, rate increased and amplitude response improved significantly. rapid immediate to was consistent mechanism postulating electron‐transfer chain is source...
Electron-accepting (electrotrophic) biocathodes were produced by first enriching graphite fiber brush electrodes as the anodes in sediment-type microbial fuel cells (sMFCs) using two different marine sediments and then electrically inverting to function cathodes two-chamber bioelectrochemical systems (BESs). Electron consumption occurred at set potentials of -439 mV -539 (versus potential a standard hydrogen electrode) but not -339 minimal media lacking organic sources energy. Results these...
An AccQ*Tag ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (AccQ*Tag-UPLC-ESI-MS/MS) method for fast, reproducible, and sensitive amino acid quantitation in biological samples, particularly, the malaria parasite Plasmodium falciparum is presented. The Waters Acquity TQD UPLC/MS system equipped with a photodiode array (PDA) detector was used separation detection. developed validated using standard mixtures containing acidic, neutral, basic acids. For...
ABSTRACT The Colilert-18 system for enumeration of total coliforms and Escherichia coli is approved by the U.S. Environmental Protection Agency use in drinking water analysis also used various agencies research studies indicator organisms fresh saline waters. During monitoring Pinellas County, Fla., marine waters, estimates E. numbers (by Colilert-18) frequently exceeded fecal coliform counts membrane filtration) 1 to 3 orders magnitude. Samples from freshwater sites did not display similar...
The alphavirus Sindbis virus (SINV) causes encephalomyelitis in mice. Lipid-containing membranes, particularly cholesterol and sphingomyelin (SM), play important roles entry, RNA replication, glycoprotein transport, budding. Levels of SM are regulated by sphingomyelinases (SMases). Acid SMase (ASMase) deficiency results the lipid storage disease type A Niemann-Pick (NPD-A), mimicked mice interruption ASMase gene. We previously demonstrated that ASMase-deficient more susceptible to fatal SINV...
Detection of Plasmodium falciparum malaria during pregnancy is complicated by sequestration parasites in the placenta, which reduces peripheral blood microscopic detection. Laser desorption mass spectrometry (LDMS) has previously demonstrated sensitive detection hemozoin from P. cultures and ability to track parasitemia a yoelii mouse model. Here we use simple, dilution water, sample preparation protocol for LDMS 45 asymptomatic, pregnant Zambian women. We compare microscopy polymerase chain...
The incidence and global distribution of chloroquine resistant (CR) Plasmodium vivax infection has increased since emerging in 1989. mechanism resistance CR P. not been defined. likely relates to the formation disposition hemozoin as chloroquine's primary action involves disruption formation. berghei strains, like are confined reticulocyte host cells reportedly they do accumulate appreciable intraerythrocytic hemozoin. Reports comparing production between strains sensitive (CS) absent. Here...
Chemical pollutants can adversely affect human and environmental health. In sediments, such as polycyclic aromatic hydrocarbons (PAHs), heavy metals pesticides have the potential to exert an array of toxic effects on susceptible organisms. Certain chemicals including dichlorodiphenyltrichloroethane (DDT), various pharmaceuticals endocrine disrupting agents (ex. nonylphenol) are recalcitrant in complicating removal. Agents dioxins bioaccumulate plant animal tissues used for consumption....
An investigation of malaria in a US patient without recent travel established Plasmodium falciparum molecular genotype identity 2 patients who shared hospital room. P. can be transmitted environment from to by blood inoculum if standard precautions are breached.
ABSTRACT Antibiotic‐resistant pathogens in public settings present a growing risk to human health. Staphylococcus aureus often asymptomatically colonizes skin, while virulent strains cause soft tissue infections, osteomyelitis, endocarditis, and are associated with cystic fibrosis. Here we investigated the presence distribution of multidrug‐resistant S. on exercise equipment university recreation facilities. Equipment sampled included barbells ( n = 10), dumbbell handles 15), kettle bell 5),...