A5040699017- RNA Interference and Gene Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Nanocomposite Films for Food Packaging
- Molecular Sensors and Ion Detection
- Block Copolymer Self-Assembly
- Nanoparticles: synthesis and applications
- Microbial Metabolism and Applications
- Enhanced Oil Recovery Techniques
- NMR spectroscopy and applications
- Cancer Immunotherapy and Biomarkers
- Plant responses to water stress
- Immunotherapy and Immune Responses
- Biocrusts and Microbial Ecology
- Nematode management and characterization studies
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Natural Fiber Reinforced Composites
- Chemical Synthesis and Analysis
- Mesoporous Materials and Catalysis
King Abdullah University of Science and Technology
2020-2024
Effective and cell-type-specific delivery of CRISPR/Cas9 gene editing elements remains a challenging open problem. Here we report the development biomimetic cancer cell coated zeolitic imidazolate frameworks (ZIFs) for targeted cell-specific this genome machinery. Coating ZIF-8 that is encapsulating (CC-ZIF) with membrane resulted in uniformly covered C3-ZIF(cell type). Incubation C3-ZIFMCF MCF-7, HeLa, HDFn, aTC lines showed highest uptake by MCF-7 cells negligible healthy (i.e., HDFn aTC)....
Delivery of antibodies using smart frameworks affords sustained and targeted activation T cells for improved immunotherapy.
Abstract The discovery of safe platforms that can circumvent the endocytic pathway is great significance for biological therapeutics are usually degraded during endocytosis. Here we show a self‐assembled and dynamic macrocycle passively diffuse through cell membrane deliver broad range biologics, including proteins, CRISPR Cas9, ssDNA, directly to cytosol while retaining their bioactivity. Cell‐penetrating CPM be easily prepared from room temperature condensation diketopyrrolopyrrole lactams...
Sustainable and precise fortification practices are necessary to ensure food security for the increasing human population. Precision agriculture aims minimize use of fertilizers pesticides by developing smart materials real-life agricultural practices. Here, we show that biomimetic mineralization can be efficiently employed encapsulate controllably release plant biostimulants (MiZax-3) improve quality yield capsicum (Capsicum annum) crops in field experiments. ZIF-8 encapsulation MiZax-3...
Fluorescent drug delivery systems have received increasing attention in cancer therapy because they combine and bioimaging into a single platform. For example, polymers with aggregation-induced emission (AIE) fluorophores, such as tetraphenylethylene (TPE), emerged an elegant choice for delivery/bioimaging applications. In this work, we report one-pot sequential organocatalytic ring-opening polymerization of ε-caprolactone (CL) ethylene oxide (EO) using TPE-(OH)2 difunctional initiator, the...
An emulsion-free approach for the preparation of hollow ZIF-8 superstructures in a single step is established based on metal sulfate hydrates methanol.
Biologically derived metal-organic frameworks (Bio-MOFs) are significant, as they can be used in cutting-edge biomedical applications such targeted gene delivery. Herein, adenine (Ade) and unnatural amino acids coordinate with Zn2+ to produce biocompatible frameworks, KBM-1 KBM-2, extremely defined porous channels. They feature an accessible Watson-Crick Ade face that is available for further hydrogen bonding load single-stranded DNA (ssDNA) 13 41% efficiency respectively. Treatment of these...
Human amylin (hIAPP) is found in the form of amyloid deposits within pancreatic cells nearly all patients diagnosed with type 2 diabetes mellitus (T2DM). However, rat (rIAPP) and pramlintide - hIAPP analogs are both non-toxic non-amyloidogenic. Their primary sequences exhibit only slight variations a few amino acid residues, primarily concentrated central region, spanning residues 20 to 29. This inspired us study this fragment investigate impact on aggregation properties substituting region...
Effective immobilization and delivery of genetic materials is at the forefront biological medical research directed toward tackling scientific challenges such as gene therapy cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting macrocycles that self-assemble into 3D through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation physiological conditions until it...
The clinical development of the anticancer drug chlorambucil (CHL) is limited by its low solubility in water, poor bioavailability, and off-target toxicity. Besides, another constraint for monitoring intracellular delivery non-fluorescent nature CHL. Nanocarriers based on block copolymers poly(ethylene glycol)/poly(ethylene oxide) (PEG/PEO) poly(ε-caprolactone) (PCL) are an elegant choice applications due to their high biocompatibility inherent biodegradability properties. Here, we have...
The international agriculture and food security sector is grappling with challenges like low crop yields, soil health deficiencies, inefficient agrochemical use. application of smart nanotechnology in agriculture, particularly surface functionalization, holds promise but has limited implementation. Engineered nanomaterials used as seed treatments, known nanopriming, offer a simple technology to improve yield stress tolerance. In this study, multicomponent platform called
Abstract The discovery of safe platforms that can circumvent the endocytic pathway is great significance for biological therapeutics are usually degraded during endocytosis. Here we show a self‐assembled and dynamic macrocycle passively diffuse through cell membrane deliver broad range biologics, including proteins, CRISPR Cas9, ssDNA, directly to cytosol while retaining their bioactivity. Cell‐penetrating CPM be easily prepared from room temperature condensation diketopyrrolopyrrole lactams...
Abstract Crystalline ZIF‐8 ( C ‐ZIF‐8 ) and amorphous Am were prepared investigated to control the germination of Striga hermonthica , a root parasitic plant, which threatens cereal crops production particularly in sub‐Saharan Africa. We have demonstrated that shows better performance than inhibiting seeds germination. This efficient materials can be attributed incomplete deprotonation 2 methylimidazole (2MIM) during amorphization, leading presence unsaturated Zn−N coordination with...
Abstract Effective immobilization and delivery of genetic materials is at the forefront biological medical research directed toward tackling scientific challenges such as gene therapy cancer treatment. Herein we present a biologically inspired hydrogen‐bonded zinc adeninate framework (ZAF) consisting macrocycles that self‐assemble into 3D through adenine‐adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation physiological conditions until...