A5019630817- Biochemical Analysis and Sensing Techniques
- Chemical Synthesis and Analysis
- Natural product bioactivities and synthesis
- Synthesis of Organic Compounds
- Marine Sponges and Natural Products
University of Szeged
2023-2024
A new family of diterpene-type aminotriol derivatives has been synthesised from stevioside in a stereoselective manner. The key intermediate spiro-epoxide was prepared through the methyl ester allilyc diol derived steviol. oxirane ring opened with primary and secondary amines, providing versatile library aminotriols. corresponding formed by palladium-catalysed hydrogenation, an N,O-heterocyclic compound regioselective reaction. All compounds were characterised 1D- 2D-NMR techniques HRMS...
A series of novel diterpene-type 1,3-aminoalcohols and their regioisomers have been synthesised from natural stevioside in a stereoselective manner. The key intermediate β-keto alcohol was prepared using Wagner–Meerwein rearrangement the epoxide derived steviol methyl ester. primary aminoalcohol formed via Raney-nickel-catalysed hydrogenation an oxime, versatile library aminoalcohols Schiff base with amines. were mesylate alcohols. corresponding palladium-catalysed hydroxyl-azide, click...