A5079023021- Multiple Myeloma Research and Treatments
- Health Policy Implementation Science
- Protein Degradation and Inhibitors
- Primary Care and Health Outcomes
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Mental Health and Patient Involvement
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Psychometric Methodologies and Testing
- Diverse Scientific Research Studies
- Lung Cancer Research Studies
- Intergenerational Family Dynamics and Caregiving
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
- Family Caregiving in Mental Illness
- Community Health and Development
- vaccines and immunoinformatics approaches
- Insect Resistance and Genetics
- Prostate Cancer Diagnosis and Treatment
University of Leeds
2011-2023
Cancer Research UK Clinical Trials Unit
2023
St James's University Hospital
2011-2017
The multicenter OPTIMUM (MUKnine) phase II trial investigated daratumumab, low-dose cyclophosphamide, lenalidomide, bortezomib, and dexamethasone (Dara-CVRd) before after autologous stem-cell transplant (ASCT) in newly diagnosed patients with molecularly defined ultra-high-risk (UHiR) multiple myeloma (NDMM) or plasma cell leukemia (PCL). To provide clinical context, progression-free survival (PFS) overall (OS) were referenced to contemporaneous outcomes seen UHiR NDMM treated the recent...
There are recognised gaps between evidence and practice in general practice, a setting posing particular implementation challenges. We earlier screened clinical guideline recommendations to derive set of 'high-impact' indicators based upon criteria including potential for significant patient benefit, scope improved amenability measurement using routinely collected data. Here, we explore health professionals' perceived determinants adherence these indicators, examining the degree which were...
Approximately half the care for people with dementia is provided by families. It therefore imperative that research informs ways of maintaining such care. In this study, we propose a needs-led approach can provide useful, novel means conceptualizing impact caring on lives family carers. Our aim was to develop and present framework understanding how providing impacts carers' fulfilment needs. qualitative conducted 42 semistructured interviews purposively diverse sample carers generate nuanced...
Interpreting evaluations of complex interventions can be difficult without sufficient description key intervention content. We aimed to develop an implementation package for primary care which could delivered using typically available resources and adapted target determinants behaviour each four quality indicators: diabetes control, blood pressure anticoagulation atrial fibrillation risky prescribing. describe the development prospective verification change techniques (BCTs) embedded within...
8001 Background: Patients with ultra high-risk (UHiR) newly diagnosed multiple myeloma (NDMM) and patients plasma cell leukemia (PCL) continue to have dismal outcomes are underrepresented in clinical trials. Recently, improved responses anti-CD38 monoclonal antibody combination therapy been reported for NDMM patients. We report here UHiR PCL treated the OPTIMUM/MUKnine (NCT03188172) trial daratumumab, cyclophosphamide, bortezomib, lenalidomide, dexamethasone (Dara-CVRd) induction, augmented...
There are recognised gaps between evidence and practice in general practice, a setting which provides particular challenges for implementation. We earlier screened clinical guideline recommendations to derive set of 'high impact' indicators based upon criteria including potential significant patient benefit, scope improved amenability measurement using routinely collected data. aim evaluate the effectiveness cost-effectiveness multifaceted, adaptable intervention package implement four...
Background Dissemination of clinical guidelines is necessary but seldom sufficient by itself to ensure the reliable uptake evidence-based practice. There are further challenges in implementing multiple and practice recommendations pressurised environment general Objectives We aimed develop evaluate an implementation package that could be adapted support a range guideline sustainably integrated within systems resources. Over five linked work packages, we developed ‘high-impact’ quality...
Action to Support Practices Implementing Research Evidence (ASPIRE) is an NIHR-funded programme aiming develop and evaluate interventions promote the uptake of NICE recommendations in general practice. Multifaceted intervention packages targeting key will be evaluated using anonymised, routinely collected electronic health records two parallel cluster randomised controlled trials (cRCTs) 144 practices across West Yorkshire. We replicate ‘real-life’ conditions under which quality improvement...
Abstract Introduction and aims Unresolved social difficulties are prevalent in oncology patients, can impact on well-being undermine ability to cope with the larger stressors of disease treatment. Information may deal psychosocial issues without over-burdening staff. A randomised pilot study investigated a specifically designed Support Services Pack (SSIP) levels distress routine practice. Methods The SSIP was evaluated. Adult patients receiving active treatment were intervention or control...