A5013438274- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Muscle Physiology and Disorders
- Viral Infections and Immunology Research
- Cholinesterase and Neurodegenerative Diseases
- Cardiovascular Function and Risk Factors
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Geochemistry and Geologic Mapping
- Online and Blended Learning
- RNA and protein synthesis mechanisms
- Hydrocarbon exploration and reservoir analysis
- Biosensors and Analytical Detection
- Atrial Fibrillation Management and Outcomes
- Problem and Project Based Learning
- Force Microscopy Techniques and Applications
- Innovative Teaching and Learning Methods
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
Washington State University
2013-2020
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCooperative Investigation of Precision and Accuracy in Chemical Analysis Silicate RocksWilliam SchlechtCite this: Anal. Chem. 1951, 23, 11, 1568–1571Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://pubs.acs.org/doi/10.1021/ac60059a014https://doi.org/10.1021/ac60059a014research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations13LEARN ABOUT...
Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) hypertrophic (HCM), respectively. Tropomyosin, together with the troponin complex, regulates contraction and, along tropomodulin leiomodin, controls uniform thin-filament lengths crucial for normal sarcomere structure function. We used Förster resonance energy transfer study effects of on kinetics cardiac core domain associated Ca2+-dependent regulation thin filaments. found that...
Calcium sensitizers enhance the transduction of Ca(2+) signal into force within heart and have found use in treating failure. However mechanisms action for most remain unclear. To address this issue an efficient fluorescence based approach to sensitizer screening was developed which monitors cardiac troponin C's (cTnC's) hydrophobic cleft. This tested on four common -sensitizers, EMD 57033, levosimendan, bepridil pimobendan with aim elucidating each as well proving efficacy new method....
Abstract Multi-Disciplinary Project-Based Paradigm that Uses Hands-on Desktop Learning Modules and Modern PedagogiesIn this CCLI Type II Program we are promoting adoption of research-based teaching pedagogiesof collaborative, hands-on, active, problem- or project-based learning (CHAPL). It has beenestablished traditional lectures ARE NOT best for student – yet is what thecommunity almost universally does! Furthermore, engineers work in broad multidisciplinaryteams while classroom individual...
Several studies have suggested that conformational dynamics are important in the regulation of thin filament activation cardiac troponin C (cTnC); however, little direct evidence has been offered to support these claims. In this study, a dye homodimerization approach is developed and implemented allows determination dynamic equilibrium between open closed conformations cTnC's hydrophobic cleft. Modulation by Ca2+, I (cTnI), T (cTnT), Ca2+-sensitizers, Ca2+-desensitizing phosphomimic cTnT...