James Harkin

ORCID: 0000-0001-6615-8941
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About
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Research Areas
  • Advanced MRI Techniques and Applications
  • Functional Brain Connectivity Studies
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cerebrovascular and Carotid Artery Diseases
  • Optical Imaging and Spectroscopy Techniques
  • Atomic and Subatomic Physics Research
  • Sharing Economy and Platforms
  • Pelvic floor disorders treatments
  • Nuclear Physics and Applications
  • ICT Impact and Policies
  • Characterization and Applications of Magnetic Nanoparticles
  • Law in Society and Culture
  • Anorectal Disease Treatments and Outcomes
  • Congenital Diaphragmatic Hernia Studies
  • Advanced Neuroimaging Techniques and Applications
  • Cardiac Imaging and Diagnostics
  • Marine and environmental studies
  • scientometrics and bibliometrics research
  • Ultrasound and Hyperthermia Applications
  • Obstructive Sleep Apnea Research
  • Respiratory Support and Mechanisms
  • Colorectal Cancer Screening and Detection
  • Marketing and Advertising Strategies

Poole Hospital NHS Foundation Trust
2023

The Christie NHS Foundation Trust
2022

Poole Hospital
2022

University Hospitals Dorset NHS Foundation Trust
2022

University of Nottingham
2019-2021

Queen's Medical Centre
2020

University of Oxford
1997-2017

Cerebrovascular reactivity mapping (CVR), using magnetic resonance imaging (MRI) and carbon dioxide as a stimulus, provides useful information on how cerebral blood vessels react under stress. This has proven to be in the study of vascular disorders, dementia healthy ageing. However, clinical adoption this form CVR been hindered by relatively long scan durations 7–12 min. By replacing conventional block presentation enriched air with sinusoidally modulated aim was investigate whether more...

10.1016/j.neuroimage.2017.07.048 article EN cc-by NeuroImage 2017-07-26

Introduction: Cerebral blood flow (CBF) is an important physiological parameter that can be quantified non-invasively using arterial spin labelling (ASL) imaging. Although most ASL studies are based on single-timepoint strategies, multi-timepoint approaches (multiple-PLD) in combination with appropriate model fitting strategies may beneficial not only to improve CBF quantification but also retrieve other information of interest. Methods: In this work, we tested several kinetic models for the...

10.3389/fphys.2023.1142359 article EN cc-by Frontiers in Physiology 2023-05-26

Abstract Cerebrovascular reactivity mapping (CVR), using magnetic resonance imaging (MRI) and carbon dioxide as a stimulus, provides useful information on how cerebral blood vessels react under stress. This has proven to be in the study of vascular disorders, dementia healthy ageing. However, clinical adoption this form CVR been hindered by relatively long scan durations 7 12 minutes. By replacing conventional block presentation enriched air with sinusoidally modulated aim was investigate...

10.1101/094359 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2017-01-16

In the UK, Institute of Physics and Engineering in Medicine (IPEM) provides guidance to Medical departments on appropriate Quality Control (QC) tests evaluate MRI scanners used routine clinical practice. The method recommended for rigorous annual assessment SNR produced by RF coils uses a sequence regions interest (ROIs) IPEM, calculates through subtraction calculation (IPEM Method). This was compared alternative methods proposed NessAiver at 2019 American Association Physicists meeting...

10.1016/j.ipemt.2022.100012 article EN cc-by-nc-nd IPEM-Translation 2022-07-01

10.1177/09564748211065901 article EN British Journalism Review 2021-12-01

10.1016/s0262-4079(14)62464-7 article EN The New Scientist 2014-12-01

ASL inversion efficiency is often assumed as a pre-defined value or estimated by acquiring an additional phase-contrast MR image. While the former approach might be inaccurate in certain conditions, latter can time-consuming. Here, we propose simplified method that estimates blood flow velocity and solely using data. This novel strategy was tested multi-PLD pCASL datasets with two different dynamics (normo- hypercapnia). Our results show feasibility of this highlight need for...

10.58530/2022/1315 article EN Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition 2023-08-03

10.1016/s0262-4079(17)32517-4 article EN The New Scientist 2017-12-01

<b>Introduction and Aim:</b> Conventional cross-sectional imaging is limited in assessing diaphragm function. The aim was to assess change volume under the dome (VuD) lateral extension of with posture breathing people bilateral palsy (BDP) using an upright MRI system. <b>Method:</b> MR images were acquired on a 0.5T supine positions during 10-seconds breath-holds at end-inspiration end-expiration. <b>Result:</b> 10 healthy volunteers (HV) 5 patients BDP scanned. In HV (mean postural FVC &lt;...

10.1183/13993003.congress-2019.pa3165 article EN Imaging 2019-09-28

10.3917/books.110.0033 article FR Books 2020-08-08

A bespoke phantom has been designed, with clinically relevant features for endoanal ultrasound (EAUS), capable of rigorously assessing the performance 360∘ probes. The three, commercially available, anorectal probes, producing both 2D and 3D images, was assessed. One probes also assessed in two states: before failure after a repair to correct failure. For each probe signal noise ratio (SNR), contrast (CNR), penetration depth, resolution, focus distance accuracy low object detectability...

10.1016/j.ipemt.2022.100007 article EN cc-by-nc-nd IPEM-Translation 2022-07-01

<b>Introduction:</b> Investigating lung disease in the pre-school population is hindered due to lack of an easily undertaken imaging modality which does not requiring ionising radiation or sedation / anaesthesia. <b>Aims:</b> To develop upright MRI awake non-sedated aged children. <b>Methods:</b> With parent/guardian consent, healthy children were sat open scanner (Paramed Medical Systems MROpen) on their parent/guardian’s lap. A coronal 2D Spoiled GRE sequence continuously acquired proton...

10.1183/13993003.congress-2021.pa353 article EN cc-by-nc Imaging 2021-09-05
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