Direct activation of gaseous hydrocarbons remains a major challenge for the chemistry community. Because intrinsic inertness these compounds, harsh reaction conditions are typically required to enable C(sp3)-H bond cleavage, barring potential applications in synthetic organic chemistry. Here, we report general and mild strategy activate bonds methane, ethane, propane, isobutane through hydrogen atom transfer using inexpensive decatungstate as photocatalyst at room temperature. The...

Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3 )-H functionalization of organic molecules. Herein, we report on unprecedented combination decatungstate photocatalysis with oxidative radical-polar crossover concept to access direct net-oxidative heteroarylation. The present methodology demonstrates high functional group tolerance (40 examples) and scalable when using continuous-flow reactor technology. developed protocol also amenable late-stage...

A strategy for both cross-electrophile coupling and 1,2-dicarbofunctionalization of olefins has been developed. Carbon-centered radicals are generated from alkyl bromides by merging benzophenone hydrogen atom transfer (HAT) photocatalysis silyl radical-induced halogen (XAT) subsequently intercepted a nickel catalyst to forge the targeted C(sp3)-C(sp2) C(sp3)-C(sp3) bonds. The mild protocol is fast scalable using flow technology, displays broad functional group tolerance, amenable wide...

Photocatalytic hydrogen atom transfer (HAT) processes have been the object of numerous studies showcasing potential homogeneous photocatalyst tetrabutylammonium decatungstate (TBADT) for functionalization C(sp3)-H bonds. However, to translate these into large-scale industrial processes, careful considerations catalyst loading, cost, and removal are required. This work presents organic solvent nanofiltration (OSN) as an answer reduce TBADT consumption, increase its turnover number lower...

Photocatalysis, as a powerful tool for synthetic transformations, has the potential to impact industrial applications. In this commentary, we discuss challenges and requirements with respect reproducing published photocatalytic reactions in (life science) industry.

We report a flow platform for the modular allylation of strong aliphatic C(sp 3 )–H bonds based on merger photocatalytic HAT and HWE reaction. This approach enables both early- late-stage diversification various hydroalkanes.

On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that difficult to be monitored in real-time. Incorporation of a pressure-based variable bed flow reactor into an automated synthesizer permitted real-time monitoring resin swelling determine amino acid coupling efficiency on-resin aggregation.

This paper describes the environmental performance of a mixed phase coating (photocatalytic nanolime) manufactured from colloidal nano-structured calcium hydroxide in alcohol (nanolime) combined with titanium dioxide. While nanolime is used as consolidant field cultural heritage and dioxide photocatalytic material for self-cleaning coatings pollution control within construction industry both materials are often separately. We report this an approach to combine development coating. The effect...

This paper describes a novel methodology for the real-time study of solid-gas phase photocatalytic reactions in situ. A reaction chamber has been designed and developed to facilitate investigation photoactive materials under different gas compositions. UV irradiation wavelength ranges 376-387 381-392 nm was provided using specially high efficiency light emitting diode arrays. The experiments used air containing 190 ppm NO2 moist environment with relative humidity 0.1%. Photocatalytic samples...

A pressure-based variable-bed flow reactor built for peptide synthesis and capable of real-time monitoring resin swelling was adapted automated glycan assembly. In the context solid-phase several oligosaccharides, coupling efficiencies, growth patterns, saccharide solvation during were determined. The presented work provides first estimation on-resin oligosaccharide an alternative technique to UV–vis monitoring.

A new photochemical CSTR system capable of handling solids in scaled continuous processes is presented. High-power UV-LEDs are integrated these CSTRs containing an insoluble base that aids generating pyrazolines

The solid-gas phase photo-catalytic activities of rutile TiO₂ and TiOn (1 < n 2) sub-oxide phases have been evaluated. Varying concentrations Ti3+ defects were introduced into the polymorph titanium dioxide through carbo-thermal reduction at temperatures ranging from 350 °C to 1300 °C. resulting sub-oxides formed characterized by X-ray diffraction, photoelectron spectroscopy, scanning electron microscopy, impedance spectroscopy UV-visible diffuse reflectance spectroscopy. presence in exposed...

Organic halides play a key role as building blocks in synthesis because of their low cost and wide availability. In recent years, halogen-atom transfer (XAT) has emerged reliable approach to exploit these substrates radical processes. Herein, we report hydroalkylation electron-poor olefins using alkyl bromides based on UVA-induced silane-mediated XAT reaction. Our protocol is operationally simple, displays broad scope does not require photocatalyst. Flow technology was used reduce the...

Abstract Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp 3 )–H functionalization of organic molecules. Herein, we report on unprecedented combination decatungstate photocatalysis with oxidative radical–polar crossover concept to access direct net‐oxidative heteroarylation. The present methodology demonstrates high functional group tolerance (40 examples) and scalable when using continuous‐flow reactor technology. developed protocol also amenable...

As peptides gained interest as new drugs in the past years, their synthetic routes had been subject of review and improvement. Fmoc/tBu-based solid-phase peptide synthesis (SPPS) is most convenient technique, implementation continuous flow has allowed for single-pass coupling deprotection reactions. The focus this research to evaluate relationship between undesired solvent-promoted reactions final crude purity, by studying volume changes a variable bed reactor through synthesis. Based on...

The late-stage introduction of allyl groups provides an opportunity to synthetic organic chemists for subsequent diversification, providing rapid access new chemical space. Here, we report the development a modular sequence allylation strong aliphatic C(sp3)–H bonds. Our features merger two distinct steps accomplish this goal, including photocatalytic Hydrogen Atom Transfer and ensuing Horner-Wadsworth-Emmons reaction. This practical protocol enables scalable valuable building blocks...

Dataset related to the paper: Environmental performance of nano-structured Ca(OH)2/TiO2 photocatalytic coatings for buildings published in Building and Environment June 2015

Photocatalytic hydrogen atom transfer (HAT) processes have been the object of numerous studies showcasing potential homogeneous photocatalyst tetrabutylammonium decatungstate (TBADT) for functionalization C(sp3)–H bonds. However, to translate these into large-scale industrial processes, careful considerations catalyst consumption, cost, and removal are required. This work presents organic solvent nanofiltration (OSN) as answer reduce TBADT increase its turnover number lower concentration in...