A5041531471- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
- Advanced Wireless Communication Techniques
- Advanced MIMO Systems Optimization
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Telecommunications and Broadcasting Technologies
- Advanced Breast Cancer Therapies
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cooperative Communication and Network Coding
- Multiple Myeloma Research and Treatments
- Blood disorders and treatments
- Multiple and Secondary Primary Cancers
- CNS Lymphoma Diagnosis and Treatment
- Satellite Communication Systems
- Wireless Communication Networks Research
Schloss Dagstuhl – Leibniz Center for Informatics
2023
University of Prishtina
2011-2022
University of Zagreb
1979-2022
Institute of Technical Sciences of SASA
2015-2020
University of Priština - Kosovska Mitrovica
2019
Klinička bolnica Merkur
2004-2018
Universidad Politécnica de Madrid
2018
Princess Margaret Cancer Centre
2015
Kingston General Hospital
2015
Hackensack University Medical Center
2015
Purpose We conducted a randomized trial to evaluate the efficacy and safety of intravenous alemtuzumab compared with chlorambucil in first-line treatment chronic lymphocytic leukemia (CLL). Patients Methods received (30 mg three times per week, for up 12 weeks) or (40 mg/m 2 every 28 days, months). The primary end point was progression-free survival (PFS). Secondary points included overall response rate (ORR), complete (CR), time alternative therapy, safety, survival. Results randomly...
Gram-positive pathogens can cause serious infections in neutropenic patients with cancer, and vancomycin therapy is often initiated empirically. Linezolid may offer an option for these patients.To compare the safety efficacy of linezolid febrile, we conducted a double-blind, multicenter equivalence study. Eligible proven or suspected infection due to gram-positive pathogen were randomized receive vancomycin.Clinical success rates 7 days after completion (primary end point) equivalent between...
Obinutuzumab (GA101), a novel glycoengineered type II anti-CD20 monoclonal antibody, demonstrated responses in single-arm studies of patients with relapsed/refractory non-Hodgkin lymphoma. This is the first prospective, randomized study comparing safety and efficacy obinutuzumab rituximab relapsed indolent The primary end point this was overall response rate (ORR) follicular lymphoma after induction lymphoma.A total 175 CD20(+) requiring therapy previous to rituximab-containing regimen were...
Total tumour mass score (TTM) is introduced as a new parameter in chronic lymphocytic leukaemia (CLL) order to assess the within all major body compartments. TTM sum of: (1) square root of number peripheral blood lymphocytes per nl, (2) diameter largest palpable lymph node centimetres, and (3) enlargement spleen below left costal margin centimetres. The validity proposed scoring system was evaluated prognostic study 256 CLL patients. Patients with high (greater than 9.0) at presentation had...
In recent years, much attention has been paid to the possible efficacy of intensive chemotherapy in treatment advanced, progressive B-cell chronic lymphocytic leukemia (CLL) patients. For this reason, International Society for Chemo-Immunotherapy, Chronic Lymphocytic Leukemia Cooperative Group, begun a randomized multicenter trial comparing Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen with continuous high dose chlorambucil (HD-CLB).During period...
The manuscript conducts a comparative analysis to assess the impact of noise on medical images using proposed threshold value estimation approach. It applies an innovative method for edge detection varying complexity, considering different types and concentrations noise. Five edges are evaluated with low, medium, high detail levels. This study focuses from three distinct datasets: retinal images, brain tumor segmentation, lung segmentation CT scans. importance is heightened in imaging, as...
Background Corticosteroids are a standard component of the treatment acute lymphoblastic leukemia and lymphoma. Our aim was to determine whether dexamethasone results in better outcome than prednisolone.Design Methods Adult patients with or lymphoma were randomized receive, as part their induction therapy on days 1–8 15–22, either 8 mg/m2 prednisolone 60 mg/m2. Those who reached complete remission given two courses consolidation high-dose cytarabine mitoxantrone methotrexate asparaginase....
Summary. It is proposed that a locally active, intrinsic renin–angiotensin system (RAS) exists in the bone marrow (BM) and plays role regulating haematopoiesis. Angiotensin II type I receptor has been detected on erythroid burst‐forming unit‐derived cells; its antagonist losartan angiotensin I‐converting enzyme (ACE) inhibitors can suppress erythropoiesis. The possible of ACE/RAS BM was investigated by evaluating ACE expression normal BM, several myeloproliferative disorders myelodysplasia....
Hypoxia frequently complicates the course of chronic obstructive pulmonary disease (COPD). Vascular endothelial growth factor (VEGF) and basic fibroblast (bFGF) are two most potent angiogenic factors may play a role in adaptation to hypoxia. The aims study were assess serum levels VEGF bFGF evaluate their mutual relationship hypoxic patients with exacerbated COPD. group consisted 50 (PaO(2) 53 mmHg) Control groups 30 stable COPD PaO(2) 70 mmHg, healthy blood donors. concentrations measured...
Abstract: In 1982 the IGCI CLL cooperative group decided to investigate usefulness of treating, at diagnosis B‐cell chronic lymphocytic leukemia (CLL) in early and stable phase disease. From January December 1986, 148 patients were randomized either receive immediate treatment with chlorambucil (CLB) or defer therapy time progression. The disease was defined by a total tumor mass (TTM) score < 9, absence anemia thrombocytopenia doubling > 12 months. main end‐point study survival. At...
Recent developments in the diagnosis and treatment of chronic lymphocytic leukemia (B-CLL) have led to change approach clinical practice.New treatments been approved based on results randomized multicenter trials for fi rst line salvage therapy, numerous ongoing are permanently providing new answers further refi ning therapeutic strategies.Th is paralleled by substantial increase understanding disease genetics due major advances next generation sequencing (NGS) technology.We defi ne current...
In order to determine the initial values and dynamic changes of EPO (erythropoietin) after therapy, 57 consecutively presenting, typical COPD (chronic obstructive pulmonary disease) patients with chronic hypoxia acute exacerbated serum levels were serially measured. Initial mean slightly above normal range (41.4±83.5 units/l), but in majority significantly reduced. Following correction hypoxaemia, decreased 14.1±16.9 units/l (P=0.0093). However, not all showed this pattern; an important...