Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) biomimics (HDL Au of different sizes and surface chemistries. The effect size chemistry on the cholesterol binding properties ability HDL NPs efflux from macrophage cells measured. Results demonstrate that may be utilized generate nanostructures with physical characteristics mimic natural HDL. Furthermore, tailored modulate bind in solution macrophages. From conjugates tested,...

Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, effect MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production nitric oxide (NO) tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. inhibited LPS/rIFN-γ-induced expression inducible synthase (iNOS) TNF-alpha release. To clarify mechanism involved, activation nuclear (NF)-kappaB was examined. The...

The Yangyang iron-oxide–apatite deposit in South Korea has undergone multiple episodes of igneous activity, deformation, hydrothermal alteration, and (IOA) mineralization. iron orebodies occur as concordant- to discordant-layered lenticular or massive magnetite and/or magnetite–pyrite ores. mineralization occurs along a N–S-trending shear zone within the syenite, which experienced both early ductile later brittle deformations. Alteration was caused mainly by injection fluid through zone,...

Abstract Metomidate and etomidate belong to the non‐barbiturate imidazole family of sedative–hypnotics elicit little analgesic action when used alone. Metomidate, in particular, has activity humans is, therefore, for veterinary purposes. In 2019, a Korean woman her twenties was found unconscious motel bath eventually died. Etomidate, alprazolam, escitalopram, metomidate were detected postmortem specimens. To our knowledge, this is first case human abuse reported Republic Korea. research,...

Primary schwannomas of the urinary bladder are extremely rare. They arise from Schwann's cells in nerve sheaths and often associated with von Recklinghausen's disease. In these cases, open partial cystectomy has been choice treatment. We performed laparoscopic a 35-year-old man who showed 3.5-cm solid mass on pelvic CT. The lesion was found to be primary schwannoma without evidence Recklinghausen

The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with circadian rhythms the aggravation stress-related conditions. In this study, we investigated effects stress, particularly continuous light exposure, on intestinal motility inflammation using zebrafish larvae a model system. We also...

A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of Grayanotoxin I (GTX I) III III) in rat whole blood. Grayanotoxins (GTXs) clindamycin as internal standard (IS) were extracted from blood via solid-phase extraction using PEP cartridges. Chromatographic separation analytes achieved on a Kinetex C18 (100 × 2.1 mm, 2.6 µm) reversed-phase column gradient elution with mobile phase 1% acetic acid water...

In this randomized, double-blind, placebo controlled clinical trial, the effects of Dendropanax morbifera (D. morbifera) Léveille on heavy metal (cadmium and mercury) excretion as well lipid peroxidation Cu, Zn-superoxide dismutase (SOD1) activity were investigated. For study, tablets containing or 300 mg leaf extract from D. used. A total 60 eligible healthy subjects enrolled in placebo-controlled study. The differences cadmium, mercury, malondialdehyde (MDA) levels SOD1 measured serum days...

Rheumatoid arthritis (RA) includes musculoskeletal symptoms that lead to disuse atrophy of muscles and changes in body composition. Musculoskeletal loss physical function may be associated with sarcopenia, which is characterized by muscle loss. This study aimed investigate the prevalence sarcopenia its association RA a Korean population. We analyzed nationwide data from Korea National Health Nutrition Examination Survey 7389 men 9798 women. Binomial logistic regression models were used...

Zizyphus jujuba is considered to have various physiological functions in the brain. We obtained a Z. methanol extract (ZJE) and observed its effects on neurogenesis middle-aged mice. Twelve-month-old mice received repeated oral administrations of ZJE for 30 days. The administration significantly increased number Ki67 (a marker cell proliferation)-positive cells subgranular zone dentate gyrus Furthermore, doublecortin neuroblast differentiation)-immunoreactive neuroblasts with tertiary...

Background/Aims Several previous studies suggest that eradication of Helicobacter pylori (H. pylori) leads to the disappearance gastric hyperplastic polyps. However, little is known about effect H. status and on recurrence polyps after endoscopic removal. Here, we investigated according final in patients who underwent removal Methods Between January 2011 December 2016, were followed-up for more than two months enrolled. The success was assessed by histology rapid urease test or urea breath...

Onion peel contains a high concentration of quercetin and other flavonoids. In this study, the potential immune-enhancing effects an onion water extract (OPE) supplement were investigated by rat forced swimming test. OPE was prepared using hot water. Thirty-six male Sprague Dawley rats fed pellet diet for 1 week then randomly divided into six groups: normal control (NC), (FSC), positive (quercetin 20 mg/kg), three groups administered 4, 20, or 100 mg/kg OPE. Oral drug administration...

A recombinant protein cannot induce sufficient immune response by itself. Various substances, including cytokine and mineral, have been used as adjuvants to enhance the immunogenicity efficacy of vaccines; however, most them excessive responses or exhibit cytotoxicity. In this study, a self-emulsifying drug delivery system (SEDDS), an isotropic mixture oil, surfactant, solvent, was designed for oil-in-water emulsions non-toxic adjuvant increase antigens.Squalene-based were prepared SEDDS...

상황버섯균주를 이용한 생물전환법으로 만들어진 바이오플라본의 항고지혈 활성에 따른 인체 외삽 적용을 위한 최소량을 살펴보고자 실험동물을 정상식이군(NO), 고지방 식이군(CO) 및 바이오플라본 식이첨가군(BFP-0.35, 0.7, 3.0)으로 나눈 후 8주간 사육하였다. 첨가 식이는 실험동물에 식이섭취량을 감소시키고 체중의 증가를 억제시켰으며, 장기 무게에 있어서도 간장과 복부지방에 CO군에 비해 유의적으로 감소함을 확인할 수 있었다(p＜0.05). 또한 총콜레스테롤, LDL-콜레스테롤, 중성지방 AI는 감소시키는데 반해 HDL-콜레스테롤은 증가하였다. 그리고 간 조직 손상정도를 나타내는 ALT AST 효소에 10% 이상의 효소감소 효과를 나타내었다. 이상과 같이 바이오플라본에는 고지혈로 야기되는 성인병 동맥경화지수를 감소시키는 생리활성 성분이 있는 것을 알 있으며 특히 모든 실험결과를 종합하였을 때 0.35%, 0.7%, 3.0% 농도 중 3% 첨가군에서 가장 큰 고지혈 감소...

Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy safety, some cases nephrotoxicity have been reported in HIV patients. Even more recently, very few Fanconi syndrome associated with tenofovir therapy monoinfection reported. Herein, we report a case 47-year-old male an monoinfection, who developed secondary osteomalacia multiple bone pain. After TDF withdrawal supplementation...

Uncontrolled chronic inflammation and necrosis is characteristic of inflammatory bowel disease (IBD). This study aimed to investigate the effect inhibitor (NI, NecroX-7) on a dextran sulfate sodium (DSS) induced colitis model mice. DSS was administered days 1-5, NI intraperitoneally (3 mg/kg, 30 mg/kg) 1, 3, 5 as well every other day during first five three-week cycle. Three cycles administration were performed. Colitis evaluated based activity index (DAI) score, colon length, histological...

A 49-year-old man visited the emergency room of Korea University Ansan Hospital with hematochezia starting day before visit. Recently, he was on anti-platelet medication due to hypertension. The patient had no definite symptoms other than hematochezia. Digital rectal exam positive and laboratory tests showed severe anemia. Sigmoidoscopy initiated almost fecal material observed in intestinal tract, allowing insertion into cecum. Active bleeding from appendiceal opening noted. On abdominal CT,...