A5000332621- RNA Research and Splicing
- Zebrafish Biomedical Research Applications
- Cancer-related molecular mechanisms research
- Retinal Development and Disorders
- Genetic and Kidney Cyst Diseases
- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- RNA modifications and cancer
- Photochromic and Fluorescence Chemistry
- interferon and immune responses
Centre for Genomic Regulation
2021-2024
Universitat Pompeu Fabra
2024
Retinal photoreceptors have a distinct transcriptomic profile compared to other neuronal subtypes, likely reflecting their unique cellular morphology and function in the detection of light stimuli by way ciliary outer segment. We discovered layer this molecular specialization revealing that vertebrate retina expresses largest number tissue-enriched microexons all tissue types. A subset these is included exclusively photoreceptor transcripts, particularly genes involved cilia biogenesis...
Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors Srrm3 Srrm4 . Disruption of these regulators mice leads severe neurological phenotypes, their misregulation is linked human disease. However, specific microexons involved phenotypes effects individual microexon deletions on neurodevelopment, physiology, behavior remain poorly understood. To explore this, we generated zebrafish lines with 18...
Abstract Actin cytoskeleton dynamics is critical for nervous system development and function, yet the role of alternative splicing in controlling these processes poorly understood. A highly conserved subset neuronal-specific microexons coordinates fundamental aspects biology. exons enriched genes involved actin cytoskeleton, their functions are unknown. Here, we focus on a microexon DAAM1, member formin-homology-2 (FH2) domain class proteins, which have diverse associated with reorganization...
Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors Srrm3 Srrm4 . Disruption of these regulators mice leads severe neurological phenotypes, their misregulation is linked human disease. However, specific microexons involved phenotypes effects individual microexon deletions on neurodevelopment, physiology, behavior remain poorly understood. To explore this, we generated zebrafish lines with 18...
Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors Srrm3 Srrm4 . Disruption of these regulators mice leads severe neurological phenotypes, their misregulation is linked human disease. However, specific microexons involved phenotypes effects individual microexon deletions on neurodevelopment, physiology, behavior remain poorly understood. To explore this, we generated zebrafish lines with 18...
ABSTRACT Retinal photoreceptors differ in their transcriptomic profiles from other neuronal subtypes, likely as a reflection of unique cellular morphology and function the detection light thorough ciliary outer segment. We discovered new layer this molecular specialization by revealing that vertebrate retina expresses largest number tissue-enriched microexons all tissue types. A subset these is included exclusively photoreceptor transcripts, particularly genes involved cilia biogenesis...