A5057305309- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Childhood Cancer Survivors' Quality of Life
- Eosinophilic Disorders and Syndromes
- Blood properties and coagulation
- Autoimmune and Inflammatory Disorders Research
- Blood groups and transfusion
- Erythropoietin and Anemia Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Biomarkers in Disease Mechanisms
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Gastrointestinal disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Multiple Myeloma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
University College of Medical Sciences
2015-2024
Guru Teg Bahadur Hospital
2014-2024
University of Delhi
2015-2024
Employees' State Insurance Model Hospital
2023
Adesh University
2018
All India Institute of Medical Sciences
2013-2017
All India Institute of Medical Sciences Bhopal
2016
All India Institute of Medical Sciences Raipur
2016
Intravenous iron sucrose is a promising therapy for increasing haemoglobin concentration; however, its effect on clinical outcomes in pregnancy not yet established. We aimed to assess the safety and effectiveness of intravenous (intervention) versus standard oral (control) treatment women with moderate-to-severe deficiency anaemia pregnancy.We did multicentre, open-label, phase 3, randomised, controlled trial at four government medical colleges India. Pregnant women, aged 18 years or older,...
Background: FNAC of intraosseous jaw lesions has not been widely utilized for diagnosis due to rarity and diversity these lesions, limited experience lack well established cytological features.Aim the study was determine role in swellings.Material Methods: 42 patients underwent over a period 7 years (2007)(2008)(2009)(2010)(2011)(2012)(2013), which 37 (88.1%)aspirates were diagnostic.Histopathology correlation available 33 cases diagnostic accuracy calculated.Results: Lesions categorized...
Background Aberrant myeloid antigen (MA) co-expression and high expression of CD34 on the blasts acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis prognosis. This study was conducted determine whether these two parameters related. Methods A total 204 cases ALL were included an analysis blast immunophenotypic data. categorized as low when less than 50% CD34-positive (CD34low) or more (CD34high). Results Of ALL, 163 41 B-cell origin (B-ALL)...
Uterovaginal prolapse frequently occurs in postmenopausal women. Hysterectomy with pelvic floor repair is one of the performed surgeries treating women who have completed their family and are not particular about preserving menstrual function. These hysterectomy specimens submitted for histopathological examination to confirm diagnosis.This study was conducted aim evaluate frequency incidental findings uteri removed assessing clinical relevance.A total 253 cases or without...
Objectives: This study aimed to compare inflammatory biomarkers (high-sensitivity {hs} C-reactive protein, neutrophil-lymphocyte ratio) and psychological morbidity in suicide attempt survivors. Methods: One hundred ninety-eight poisoning cases screened, 40 age-matched survivors (SAS), healthy controls (HC) between the age of 18 years 60 were included. Complete hemogram, ratio (NLR), hsCRP values obtained, compared with Hospital Anxiety Depression Scale (HADS), intent scale, presumptive...
Introduction Plasma antioxidant capacity in children receiving chemotherapy decreases due to the effect of disease and chemotherapy. Increased oxidative stress (OS) predisposes an increased risk for chemotherapy-related toxicity febrile neutropenic episodes. Materials methods We conducted this case-control study hematology-oncology unit department pediatrics a tertiary hospital Delhi, India, from November 2017 March 2019 compare OS between with acute lymphoblastic leukemia (ALL) healthy...
The purpose of this study was to characterize differences in the prevalence hereditary and acquired thrombophilia patients with splanchnic vein thrombosis (SVT). A total 88 consecutive SVT, including Budd Chiari Syndrome (n = 47) portal extrahepatic obstruction 41), underwent comprehensive testing, testing for heritable causes. In 33 (37.5%) patients, etiology could be explained by at least 1 etiologic factors, 31 (35.2%) causes studied. combination multiple concurrent factors present 9...
To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease.This cross-sectional analytical study was conducted among aged 1 12 years age moderate-to-severe iron deficiency and control without anemia. Serum IgA-tissue trans-glutaminase levels were assessed in both cases controls. All positive serology underwent upper gastrointestinal endoscopy duodenal biopsy; biopsy finding Marsh grade 3 considered for disease.There 152 anemic...
Bleeding is a common clinical presentation. Even patients with mild bleeding disorders are extensively investigated for ascertaining the cause. The present study was conducted in order to evaluate extent of possibility diagnosis disorders.This prospective referred work up period 13 months. A complete blood count, peripheral smear examination, Prothrombin time, Partial Thromboplastin time and Thrombin Time, Platelet Aggregometry test, tests von Willebrand's disease Factor 3 availability were...
Bone marrow iron estimation remains the gold standard for diagnosing iron-deficiency anemia (IDA); serum ferritin, total iron-binding capacity, and transferrin saturation are routinely used as surrogate markers of IDA. However, these tests marred by problems like poor specificity sensitivity. Recently, hepcidin, a protein hormone synthesized in liver excreted urine, has been shown to be related status. We estimated urinary hepcidin levels healthy children 6 60 months age with (n=30) without...
Head injury causes disseminated intravascular coagulation as the most severe complication which is associated with high mortality. Elevated levels of markers fibrinolysis such D-dimer and fibrinopeptide A (FPA) have been correlated poor outcome in these patients.The study aimed to correlate plasma fibrinogen, D-dimer, FPA patients isolated head trauma.This cross-sectional descriptive was conducted Departments Pathology Neurosurgery, University College Medical Sciences Guru Teg Bahadur...
Adrenal insufficiency can often manifest with nonspecific complaints. Primary adrenal lymphoma is a rare cause of insufficiency. We present the case 55-year-old female who presented complaints abdominal pain, pallor and weight loss was found to have primary lymphoma. The highlights need expeditiously initiate steroid replacement in patients insufficiency, while efforts are made establish etiology
ABSTRACT INTRODUCTION: Aberrant expression of immunophenotypic markers is commonly found in patients acute leukemia. T-ALL also shows aberrant such as CD13, CD33, CD117, CD10, and CD79a. Morphologically, has been categorized into L1, L2, L3 subtypes. Till now, no study done to correlate these with morphological features T-ALL. This aimed the morphology MATERIALS AND METHODS: All cases diagnosed by flow cytometry over a period 2½ year were taken out from records Hematology Section Department...
Background: Inflammation has several effects in the geriatrics with reference to iron deficiency anemia (IDA), of chronic disease (ACD), and unexplained (UA). Whether hyperinflammation is part their pathogenesis or just incidental unknown. Data are limited regarding inflammatory patterns IDA, ACD, UA anemic inflammation as a component UA. There little known about overlap between ACD Objective: The study was undertaken find proportion geriatric patients, aged ≥60 years raised serum levels...
Imatinib, a tyrosine kinase inhibitor, is the cornerstone in treatment of CML [1,2].Earlier was treated with Busulphan which normalised only peripheral counts, while hydroxyurea addition showed mild regression marrow changes also.Interferon (IFN a) had similar effects to but it caused progression myelofibrosis.None earlier drugs reduced disease burden by reducing Ph+ stem cells [3].Imatinib selectively targets bcr/abl and also inhibits other kinases namely Platelet Derived Growth Factor...
Background: Bone marrow examination is crucial diagnostic modality for evaluation of various hematological and nonhematological disorders. However, aspirate smears biopsy sections, even though performed simultaneously, are often assessed at different points time due to processing methods. This sometimes results in discordance diagnosis which adds the dilemma delays treatment.aim: study aims compare accuracy rate concordance between two modalities bone examination.Materials Methods: Three...
In the female genital tract, lymphangiomas have been described commonly in cervix, uterus and fallopian tubes (Siddall Clinton 1937). Ovarian lymphangioma is an extremely rare entity with a...
Introduction Central nervous system (CNS) treatment using intrathecal chemotherapy and cranial radiation to enable long-term disease-free survival from childhood acute lymphoblastic leukemia (ALL) comes at the cost of neurotoxic side effects sequelae. We investigated oxidative stress as a possible mechanism chemotherapy-induced neurotoxicity in children with ALL. Materials methods In this case-control study, we estimated cerebrospinal fluid (CSF) levels 8-hydroxy-deoxyguanosine (8-OH-dG),...