A5047621042- Diabetes Treatment and Management
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Plant Toxicity and Pharmacological Properties
- Berberine and alkaloids research
- Silymarin and Mushroom Poisoning
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
Universidade Estadual do Centro-Oeste
2023-2025
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and typically administered via subcutaneous injections. Oral delivery, although more desirable being painless potentially enhancing patient adherence, challenged by the peptide’s low bioavailability vulnerability to digestive enzymes. This study aimed develop LIRA-containing zein-based nanoparticles stabilized with eudragit RS100 chitosan oral use...
Silybin (SLB), an important flavonoid from silymarin, displays significant hepatoprotective, anticancer, antioxidant, and neuroprotective effects. However, its therapeutic efficacy is limited by low solubility bioavailability. To address these challenges, we engineered bovine serum albumin (BSA) nanoparticles (NP) loaded with SLB (BSA-NP/SLB) using the coacervation method. BSA-SLB NP exhibited a spherical shape, mean size of 197 nm, polydispersity index 0.275, zeta potential -34 mV,...