A5068096638- Synthesis and biological activity
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- ATP Synthase and ATPases Research
- Metal complexes synthesis and properties
- Chemical Reaction Mechanisms
- Enzyme function and inhibition
- Inflammatory mediators and NSAID effects
- Cancer therapeutics and mechanisms
- Mitochondrial Function and Pathology
Dicle University
2021-2023
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Objective: In addition to its role in the formation mechanism of inflammation, binding potential COX inhibitors, which can inhibit tumorogenesis by induce apoptosis, has been explored molecular docking studies on wild-type RAS enzyme. Material and Method: KRAS enzyme (PDB ID: 4OBE), consists is obtained x-ray crystallization method, was chosed considering resolution. The 2D structures ligand molecules were drawn ChemDraw 19.1. MOE 2020 program used form studies. Result Discussion: As a...
Objective: The first goal of the present study is to investigate role mitochondria due Crabtree effect in HepG2 cells exposed ISO either glucose- or galactose-conditioned media. second aim predict interactions between electron transport chain (ETC) complexes and ISO, which might be possible reason for mitochondrial dysfunction. Material Method: Cell viability membrane damage (12.5, 25, 50, 100, 250 µM) were assessed by MTT LDH leakage assays affinity ETC was also determined a molecular...
Aim: This study aims to evaluate the alterations in Oxypeucedanin (OXY)-mediated anticancer activity different media. Second aim is predict affinity of OXY electron transfer chain (ETC) complexes. Materials and Methods: MTT LDH leakage assays were performed with OXY. Molecular docking studies also conducted ETC Results: 250 µM reduced viability glucose ≥50 decreased galactose increased membrane disruption showed that might possess capacity bind inhibition sites Complex I IV. Conclusion:...