A5042826476- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Protease and Inhibitor Mechanisms
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Lanthanide and Transition Metal Complexes
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
Niigata University
2019-2020
The University of Tokyo
2019
National Center of Neurology and Psychiatry
2019
Vanishing white matter disease (VWM) is an autosomal recessive neurological disorder caused by mutation(s) in any subunit of eukaryotic translation initiation factor 2B (eIF2B), activator eIF2. VWM occurs with mutation the genes encoding eIF2B subunits (EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5). However, little known regarding underlying pathogenetic mechanisms or how to treat patients VWM. Here we describe identification detailed analysis a new spontaneous mutant mouse harboring point...
Many of the focal neurological symptoms associated with Alzheimer’s disease (AD) are due to synaptic loss. Glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) is a candidate method assess dysfunction. We assessed chronological changes in GluCEST 5xFAD mouse model AD, comparing Glucest effects and regional cerebral blood flow (CBF). CBF mice aged 1–15 months their littermates (WT) were measured. Neurite orientation dispersion density (NODDI) MRI...
Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of most severe side effects thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes distribution MMPs brain. Here, we developed a new 19 F-molecular ligand, TGF-019, for visualizing vivo using F-magnetic resonance spectroscopic...