A5101831936- Sperm and Testicular Function
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Muscle and Compartmental Disorders
- Reproductive biology and impacts on aquatic species
- Tendon Structure and Treatment
Peking University Shenzhen Hospital
2020-2024
University of Hong Kong - Shenzhen Hospital
2020-2024
Abstract Metastasis is the main cause of cancer-associated deaths, yet this complex process still not well understood. Many studies have shown that acetate involved in cancer metastasis, but molecular mechanisms remain to be elucidated. In present study, we first measured effect on zinc finger transcriptional repressor SNAI1 and acetyl-CoA synthetase 2 (ACSS2) under glucose limitation renal cell carcinoma lines, 786-O ACHN. Then, RNA interference overexpression ACSS2 were used detect role...
Asthenozoospermia (AZS), diagnosed by reduced sperm motility, is one of the major causes male infertility. However, AZS has no effective therapeutic treatment and underlying molecular mechanism remains largely unclear. In this study, state-of-the-art 4D-quantitative proteomics analysis was used to compare protein profiling between 7 normozoospermic 11 asthenozoospermic samples. Overall, 4718 proteins were identified 1430 differential abundant found in two groups. The differentially expressed...
Abstract One hallmark of renal cell carcinoma (RCC) is metabolic reprogramming, which involves elevation glycolysis and upregulation lipid metabolism. However, the mechanism reprogramming incompletely understood. Monocarboxylate transporter 1 (MCT1) promotes transport for lactate pyruvate, are crucial The aim present study was to investigate function MCT1 on RCC development its reprogramming. results showed that messenger RNA protein levels significantly increased in cancer tissues ccRCC...
Abstract Asthenozoospermia (AZS) is a prevalent contributor to male infertility, characterized by substantial decline in sperm motility. In recent years, large‐scale studies have explored the interplay between reproductive system's microecology and its implications for health. Nevertheless, direct association seminal infertility pathogenesis remains inconclusive. This study used 16S rDNA sequencing multi‐omics analysis conduct comprehensive investigation of microbial community metabolites...
Non-obstructive azoospermia (NOA) is the most severe form of male infertility owing to absence sperm during ejaculation as a result failed spermatogenesis. The molecular mechanisms NOA have not been well studied. Here, we revealed dysregulated differentially expressed genes in and related signaling pathways or biological processes. Cluster features processes include spermatogenesis, fertilization, cilium movement, penetration zona pellucida, chromatin condensation, being significantly...