A5001179120- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Advanced Neuroimaging Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
ETH Zurich
2007-2018
Institute for Biomedical Engineering
2011
Loss of oligodendrocytes is a feature many demyelinating diseases including multiple sclerosis. Here, we have established and characterized novel model genetically induced adult oligodendrocyte death. Specific primary loss leads to well defined highly reproducible course disease development that can be followed longitudinally by magnetic resonance imaging. Histological ultrastructural analyses revealed progressive myelin vacuolation, in parallel includes motor deficits, tremor, ataxia....
Myelination calls for a remarkable surge in cell metabolism to facilitate lipid and membrane production. Endogenous fatty acid (FA) synthesis represents potentially critical process myelinating glia. Using genetically modified mice, we show that Schwann (SC) intrinsic activity of the enzyme essential de novo FA synthesis, synthase (FASN), is crucial precise composition peripheral nerves fundamental correct onset myelination proper myelin growth. Upon FASN depletion SCs, epineurial adipocytes...
Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or Schwann (SCs). However, the signals that determine which type of cell is generated and underlying mechanisms involved have not been identified. Here, we show distinctive microenvironments created in discrete niches within demyelinated white matter fate decisions adult OPCs. By comparative transcriptome profiling demonstrate an ectopic,...