A5055648482- Dialysis and Renal Disease Management
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- ATP Synthase and ATPases Research
- Pregnancy and preeclampsia studies
- Biomedical Research and Pathophysiology
- Reproductive Biology and Fertility
- Retinal Imaging and Analysis
- Effects and risks of endocrine disrupting chemicals
- Integrated Circuits and Semiconductor Failure Analysis
- Neonatal Health and Biochemistry
- Molecular Biology Techniques and Applications
- Microplastics and Plastic Pollution
- PARP inhibition in cancer therapy
- Metabolism and Genetic Disorders
- Lung Cancer Research Studies
- Acute Kidney Injury Research
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Nephrotoxicity and Medicinal Plants
- Retinal Diseases and Treatments
Chongqing Medical University
2023-2025
Government of Western Australia Department of Health
2025
Institute for Human Reproduction
2025
Nantong University
2022-2024
Affiliated Hospital of Nantong University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanghai University of International Business and Economics
2023
Chongqing Public Health Medical Center
2023
Taiyuan Institute of Technology
2021
Nanoplastics have recently emerged as persistent pollutants of global concern that pose substantial risks to human health. However, the long-term adverse effects nanoplastics on female reproductive system remain unclear. Polystyrene (PS-NPs; 50 nm diameter) were selected representative nanosized plastic particles investigate potential subchronic prenatal and gestational exposure via drinking water placental development in ICR (CD-1) mice. Maternal 10 mg/L PS-NPs induced an increase fetal...
Impaired mitochondrial function and dysregulated energy metabolism have been shown to be involved in the pathological progression of kidney diseases such as acute injury (AKI) diabetic nephropathy. Hence, improving is a promising strategy for treating renal dysfunction. NADH: ubiquinone oxidoreductase core subunit V1 (NDUFV1) an important complex I. In present study, we found that NDUFV1 was reduced kidneys ischemia/reperfusion (I/R) mice. Meanwhile, I/R induced dysfunction evidenced by...
Aristolochic acid I (AAI), the predominant compound in Aristolochiaceae plants and Asarum species, is a widespread environmental contaminant capable of accumulating soil, contaminating water crops, ultimately entering human body. Its nephrotoxic, carcinogenic, reproductive toxic effects pose significant health concerns. This study investigates impact maternal AAI exposure on meiotic prophase (MPI) during early fetal oogenesis. Pregnant mice were orally administered at doses 0.03125, 0.125, 1...
The clinical significance of homologous recombination deficiency (HRD) in breast cancer, ovarian and prostate cancer has been established, but the value HRD non-small cell lung (NSCLC) not fully investigated. This study aimed to systematically analyze status untreated NSCLC its relationship with patient prognosis further guide care. A total 355 treatment-naïve patients were retrospectively enrolled. was assessed using AmoyDx Genomic Scar Score (GSS), a score ≥50 considered HRD-positive....
Abstract Backgroud Supernatants from various cytological samples, including body cavity effusion, sputum, bronchoalveolar lavage fluid (BALF), and needle aspiration, have been validated for detecting genetic alterations using cell‐free DNA (cfDNA) in patients with non‐small cell lung cancer (NSCLC). However, the sensitivity of fusion variations detection remains challenging. The protection RNA (cfRNA) is critical resolving issue. Methods A protective solution (PS) was applied preserving...
Failure to control blood glucose level (BGL) may aggravate oxidative stress and contribute the development of diabetic nephropathy (DN). Using erythrocytes (ERs) as carriers, a smart self-regulatory insulin (INS) release system was constructed INS according changes in BGLs improve patients' compliance health. To overcome limited sources ERs decrease risk transmitting infections, we developed an vitro, closed-loop autologous ER-mediated delivery (CAER) platform, based on commercial...
Acute kidney injury (AKI) is a common and life-threatening condition associated with cell death, where ferroptosis plays critical role. Chemerin, primarily produced in white adipose tissue, has multiple biological functions renal pathophysiology. However, to date, whether how chemerin regulates the progression of AKI remain unclear. Here, we found that expression was reduced both model mice cells. Similarly, serum levels were also decreased patients. The administration recombinant improves...
Ophthalmic diseases have globally afflicted visual functioning and activities of daily living for many people. Among these vision-threatening disorders, glaucoma, diabetic retinopathy, cataracts constitute major causes deficit. Although preventative diagnosis could precluded the development vision loss in individuals, suitable screening methods early detection ophthalmic not yet been explored. This study presents an disease diagnostic assistance system powered by deep learning algorithms,...