A5072822168- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Planarian Biology and Electrostimulation
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Knee injuries and reconstruction techniques
- biodegradable polymer synthesis and properties
- Shoulder Injury and Treatment
- Periodontal Regeneration and Treatments
- Osteoarthritis Treatment and Mechanisms
- Surgical Sutures and Adhesives
- Advanced X-ray and CT Imaging
- Spaceflight effects on biology
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Bone and Dental Protein Studies
Henry Royce Institute
2020-2025
University of Manchester
2016-2025
Keele University
2002-2013
Yale University
2012
Georgia Institute of Technology
2002-2006
University Hospitals of North Midlands NHS Trust
2005
University of Liverpool
1998
Cellular activity at the center of tissue-engineered constructs in static culture is typically decreased relative to construct periphery because transport limitations. We have designed a tissue system that perfuses medium through three-dimensional (3D) porous cellular improve nutrient delivery and waste removal within constructs. This study examined effects perfusion rate on cell viability, proliferation, gene expression cell-seeded 3D bone scaffolds. Human trabecular scaffolds were seeded...
Abstract The capability of electrical stimulation (ES) in promoting bone regeneration has already been addressed clinical studies. However, its mechanism is still being investigated and discussed. This study aims to investigate the responses macrophages (J774A.1) preosteoblasts (MC3T3‐E1) ES faradic by‐products from ES. It found that pH culture media was not significantly changed, whereas average hydrogen peroxide concentration increased by 3.6 5.4 µM after 1 2 hr ES, respectively....
Electrical stimulation of cells allows exogenous electric signals as stimuli to manipulate cell growth, preferential orientation and bone remodelling. In this study, commercially pure titanium discs were utilised in combination with a custom-built bioreactor investigate the cellular responses human mesenchymal stem via in-vitro functional assays. Finite element analysis revealed homogeneous delivery field chamber no detection current density fluctuation proposed model. The capacitive system...
Abstract Modulating cellular functions at the dental implant‐tissue interface to augment integration and prevent bacterial ingress is crucial for achieving early stability long‐term implant success. Nano‐engineering strategies, such as anodized titanium implants with titania (TiO 2 ) nanotubes/nanopores, are emerging a promising surface modification approach enhance infection. Achieving on‐demand therapy through electrical stimulation (EST, supply of voltage/current local tissue) may be...
Biological tissues are exposed to X-rays in medical applications (such as diagnosis and radiotherapy) research studies (for example microcomputed X-ray tomography: microCT). Radiotherapy may deliver doses up 50Gy both tumour healthy tissues, resulting undesirable clinical side effects which can compromise quality of life. Whilst cellular responses relatively well-characterised, X-ray-induced structural damage the extracellular matrix (ECM) is poorly understood. This study tests hypotheses...
Abstract Reconstruction of large bone defects is still a major problem. Tissue‐engineering approaches have become focus in regeneration bone. In particular, critical‐sized do not ossify spontaneously. The use electrospinning attracting increasing attention the preparation tissue‐engineering scaffolds. Recently, acellular scaffolds carrying bioactive agents been used as “ situ ” tissue engineering for soft and hard repair. Poly(ϵ‐caprolactone) (PCL) with two different molecular weights were...
This research presents the first optimised protocol for submersion of electrospun polycaprolactone (PCL) fibres in sodium hydroxide (NaOH) to improve surface hydrophilicity, and hence biocompatibility, without compromising material properties. The study comprised two aims: (1) identify leading NaOH concentration (0, 0.1, 1, 10 M) time 4, 24 h) hydrophilicity with minimal impact on tensile properties (2) once identified, undertake characterisation vitro testing validation. 1 M 4 h (NaOH...
Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric has been barely reported percolated conductive biopolymers. In context, electroactive polycaprolactone (PCL) scaffolds with Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by 3D printing method. Under direct current (DC) along the scaffolds, strong antibacterial was...