Citrus fruits have potential health-promoting properties and their essential oils long been used in several applications. Due to biological effects described some citrus species this study our objectives were analyze compare the phytochemical composition evaluate anti-inflammatory effect of (EO) obtained from four different species. Mice treated with EO C. limon, latifolia, aurantifolia or limonia (10 100 mg/kg, p.o.) evaluated chemical induced inflammation (formalin-induced licking...

Hancornia speciosa Gomes (Apocynaceae) is a tree that widely distributed throughout Brazil. Its latex collected and used extensively to treat acne, warts, diseases related bursitis, inflammation. In this work, we describe the anti-inflammatory effects of latex.The from (0.06-1.3mg/kg, p.o.) reference drug acetylsalicylic acid (ASA, 200mg/kg, were evaluated in analgesia (formalin-induced licking, acetic acid-induced contortions, hot plate) inflammation models paw oedema, subcutaneous air...

Copaiba oil resin (COR) obtained from Copaifera multijuga Hayne has been used in popular medicine as an antinflammatory and for the treatment of bronchitis, ulcers cancer. The aim this study was to evaluate action COR its fractions on inhibition lung metastasis tumour growth induced by B16F10 melanoma cells mice cytotoxicity vitro using Trypan Blue exclusion method MTT conversion. Mice which have received subcutaneously developed a solid that reached peak at 17 days. Together with increase...

Abstract Background Teas from the husk fiber of Cocos nucifera are used in folk medicine to treat arthritis and other inflammatory processes. Some works show that some varieties have biological activities. However, one main variety species, C . var. typica , known Brazil as “gigante”, was not studied yet. Thus, this study evaluates if has anti-inflammatory antimicrobial activities already reported varieties. Methods aqueous crude extract (10, 50, 100 mg/kg) reference drugs morphine (1...

Lippia origanoides Kunth. Verbenaceae, is of great importance in the Brazilian traditional medicine. Because it, this work had purpose to contribute ethnopharmacological knowledge L. through an ethnobotanical survey conducted within quilombola (maroon) communities Oriximiná, Pará, Brazil. Among 254 plants cited survey, stood out among ten most versatile species. The agreed main uses were treat menstrual cramps, stomachache, and baby postpartum colic. This could indicate a consensus...

Copaifera multijuga Hayne (Leguminosae) is a tree that produces an oleoresin, which extensively commercialized in Brazil as capsules or crude oil for the treatment of several disorders. Ethnopharmacological studies show diversity indications such anti-inflammatory and epidermal wound cicatrization.In present work three fractions obtained from oleoresin (hexane (HF), chloroform (CF), methanol (MF) KOH impregnated silica gel column chromatography, representing main classes compounds genus...

Couroupitaguianensis Aubl. (Lecythidaceae) is popularly known in Brazil as "abricó-de-macaco". Infusions or teas obtained from its leaves, flowers, and barks are used South America for the treatment of several disorders such pain inflammatory processes.Evaluate antinociceptive effects crude ethanol extract (CEE) fractions three analgesic models (acetic acid-induced contortions, tail flick, hot plate) study possible mechanism their action.CEE, hexane, dichloromethane, ethyl acetate, butanol...

The species Lippia gracilis Schauer, known in Brazil as "Alecrim-da-chapada", is popularly used folk medicine to treat cough, bronchitis, nasal congestion, and headache. essential oil (EO; 10, 30, 100 mg/kg, p.o.) the reference drugs morphine (5 acetylsalicylic acid (ASA; 200 were evaluated using models for analgesia (acetic acid-induced contortion, formalin-induced licking, hot plate) or inflammation (formalin-induced licking response subcutaneous air pouch model). To elucidate...

Cocos nucifera cultivated in Brazil is known as "coco-da-Bahia" or "coqueiro-da-India". The tea from the husk fiber widely used to several inflammatory disorders. Crude extract and fractions obtained "common variety" were evaluated test anti-inflammatory antinociceptive activities.Crude (CE, 50, 100, 150 mg/kg), fraction 1 (F1, molecular weight lesser than kDa, 1, 10, 50mg/kg), 2 (F2, higher references drugs morphine (5mg/kg), acetilsalicilic acid (200mg/kg), prometazine (30 metisergide...

Couroupita guianensis Aublet, 'macacarecuia', 'abricó-de-macaco', 'castanha-de-macaco' and 'amêndoa-dos-andes', is found in tropical regions widely used the treatment of tumors, pain, inflammatory processes.Ethanol extract hexane ethyl acetate fractions were evaluated models pain (formalin-induced licking) acute inflammation (carrageenan-induced peritonitis).Ethanol extract, (10, 30 or 100 mg/kg, p.o.) reference drugs dexamethasone (5 mg/kg), morphine s.c.), acetylsalicylic acid (100 tested...

Babassu is the common Brazilian name of Orbignya speciosa Mart. (Arecaceae). The fruits are used for several disorders. In present study, antinociceptive effects ethanol extract (EE) and dichloromethane fraction (DF) obtained from leaves were investigated, as well apigenin using nociception models (acetic acid-induced abdominal writhing, formalin, hot plate). Mice treated with EE, DF (10, 30, 100 mg/kg, p.o.), (1 morphine (5 s.c.), acetylsalicylic acid (100 p.o.) or vehicle (0.1 ml, p.o.)....

Convolutamydine A, an oxindole that originated from a marine bryozoan, has several biological effects. In this study, we aimed to investigate the antinociceptive effects of convolutamydine A and two new synthetic analogues. analogues were given orally assess their ability induce Formalin-induced licking response, acetic acid-induced contortions, hot plate models used characterize its (4,6-bromo-3-(2-oxopropyl)-3-hydroxy-2-oxindole), compound 1 (3-(2-oxopropyl)-3-hydroxy-2-oxindole), 2...

Abstract Targeting histone deacetylases (HDACs) and phosphatidylinositol 3‐kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacological profile, molecular modeling of novel class N ‐acylhydrazone (NAH) derivatives that act as HDAC6/8 PI3Kα dual inhibitors. The surprising selectivity may be related to differences conformation active site. Cellular studies showed these compounds HDAC6 inhibition PI3/K/AKT/mTOR...

The injection of 100 or 300 μg carrageenin into the mouse paw pleural cavity produced a delayed inflammatory reaction at 48 h while platelet activating factor (PAF)‐induced oedema and pleurisy were maximal 30 min after its injection. PAF antagonist, WEB 2086, failed to inhibit induced by PAF, but reduced first phase (1–4 h) without interfering with second one (48–72 h). In contrast, another structurally‐related 2170, inhibited dose‐dependently both (48 Repeated injections led significant...