A5077433476- Malaria Research and Control
- Global Maternal and Child Health
- Photodynamic Therapy Research Studies
- Parasites and Host Interactions
- Nanoplatforms for cancer theranostics
- HIV/AIDS drug development and treatment
- Child Nutrition and Water Access
- Pharmacological Effects and Toxicity Studies
- Streptococcal Infections and Treatments
- Global Public Health Policies and Epidemiology
- Drug Transport and Resistance Mechanisms
- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Infective Endocarditis Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Ethnobotanical and Medicinal Plants Studies
- Antibiotic Use and Resistance
- Cardiovascular Effects of Exercise
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Helminth infection and control
- Pharmaceutical Quality and Counterfeiting
- Cardiomyopathy and Myosin Studies
- Iron Metabolism and Disorders
- Medication Adherence and Compliance
Muhimbili University of Health and Allied Sciences
2016-2025
Karolinska University Hospital
2019-2020
Karolinska Institutet
2019
Boston University
2012
University of Massachusetts Boston
2012
KU Leuven
1998-2006
Tanzania has recently experienced a significant rise in the burden of diabetes, and it is estimated that more than 400,000 people are living with diabetes. A major concern management diabetes occurrence diabetic complications occur as result poor glycemic control. Identification factors associated control important order to institute appropriate interventions for purpose improving prevention chronic complications.The aim this study was determine level explore among patients type 2 mellitus...
Abstract In Tanzania, chloroquine was replaced by sulphadoxine- pyrimethamine (SP) as a first-line for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP lasted only 5 years and the end 2006 it with current artemisinin combination therapy. We therefore, set study determine genotypic mutations associated Plasmodium falciparum artemisinin, partner drugs chloroquine. Parasites DNA were extracted from dried blood spots collected finger-prick Tanzanian infected...
The increased access to medicinal products in Africa is not well-matched with the pharmacovigilance capacity monitor drug safety. objective of this study was assess functionality and identify strengths limitations national systems Ethiopia, Kenya, Rwanda, Tanzania, compare these systems. Legal statutory documents governing each participating country were examined by assessors prior on-site review. staff unit National Medicines Regulatory Authorities (NMRAs) interviewed using East African...
Background: The efficacy and safety of photodynamic therapy for superficial bladder cancer depend on tumor-selective accumulation the photosensitizer. Bladder transitional-cell carcinoma cells overexpress transferrin receptor their surface. We examined whether transferrin-mediated liposomal targeting photosensitizer aluminum phthalocyanine tetrasulfonate (AlPcS 4 ) is an effective strategy to attain this compound when applied intravesically. Methods: AlPcS was stably encapsulated in...
Background Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due its endemicity, co-infection with malaria common. The diseases anaemia impaired nutritional status among children. We investigated the prevalence of intestinal schistosomiasis association malaria, school Methods This was cross sectional survey 830 children Nyamikoma village along Lake Victoria Tanzania. A pre-tested questionnaire used collect socio-demographic...
For rheumatic mitral stenosis (MS), a multidisciplinary evaluation is mandatory to determine the optimal treatment: medical, percutaneous balloon valvuloplasty (PBMV) or valve surgery. Clinical and imaging evaluations are essential for procedural risk assessment outcomes. PBMV interventions increasingly available in Africa feasible options selected candidates. Enhancing training/skills transfer across most of African countries possible.
Background The provision of clinical pharmacy services (CPS) in low- and middle-income countries is still low. reported challenges providing CPS include healthcare structures, public policies, resources, workforce, culture education inequalities. This study aimed to explore the strategies improve tertiary health facilities Tanzania. Methods was conducted between August September 2021. We adopted an exploratory qualitative conduct 14 in-depth interviews with hospital administrators 10 focus...
Like other Sub-Saharan Africa (SSA) countries, Tanzania is undergoing socio-economic changes that impact lifestyles and dietary choices. Traditionally, differences in habits between rural urban areas SSA countries were prominent. However, recent research indicates converging choices associated with increased risk of cardiometabolic diseases. The objective the current study was hence to investigate similarities patterns, energy, food groups intake Tanzania. Dietary assessed by use a Food...
Background Addressing sickle cell disease (SCD) is crucial for achieving health-related Sustainable Development Goals, particularly in Africa. The region significantly affected, with 78.7% of patients SCD residing sub-Saharan Africa and over 515 000 newborns diagnosed annually. Historically, African health systems have struggled to provide optimal care SCD, resulting high under-5 mortality severe childhood morbidity. Scientific innovations stakeholder engagement offer hope improving...
Asymptomatic malaria and anemia during pregnancy increase the risk of negative birth outcomes. This cross-sectional study investigated prevalence correlates asymptomatic first antenatal care (ANC) visit among pregnant women in a rural district, Tanzania. HIV-uninfected without symptoms (n = 819) attending their ANC at Kibiti Health Centre were enrolled from February 2017 to 2018. was detected by rapid-diagnostic tests (mRDT) real-time PCR. Hemoglobin concentration determined HemoCue 201+....
Despite the reported success in reducing morbidity, praziquantel alone is insufficient for control and elimination of schistosomiasis, partly due to its poor efficacy against juvenile worms. Artemisinin derivatives are effective worms but less adult We compared safety Dihydroartemisinin-piperaquine combination standard treatment intestinal schistosomiasis.In this randomized, open-label, non-inferiority trial, 639 Schistosoma mansoni infected children were enrolled randomized receive either...
This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children adolescents in Tanzania.
Collaboration between medical doctors and nurses in the provision of healthcare services has been there for decades. The concept clinical pharmacy as a main goal practice is relatively new yielding more positive results providers (HCPs), patients, health system. This study assessed barriers facilitators toward integration pharmacists CPS Tanzania.
HIV-malaria co-infected patients in most parts of sub-Saharan Africa are treated with both artemether-lumefantrine (AL) and efavirenz (EFV) or nevirapine (NVP)-based antiretroviral therapy (ART). EFV, NVP, artemether lumefantrine substrates, inhibitors inducers CYP3A4 CYP2B6, creating a potential for drug-drug interactions. The effect EFV and/or NVP on pharmacokinetic profile among ART AL was investigated. Optimal dosage regimen EFV-based determined by population pharmacokinetics...
Pregnancy has considerable effects on the pharmacokinetic properties of drugs used to treat uncomplicated Plasmodium falciparum malaria. The role pharmacogenetic variation anti-malarial drug disposition and efficacy during pregnancy is not well investigated. study aimed examine effect pharmacogenetics lumefantrine (LF) pharmacokinetics treatment outcome in pregnant women. Pregnant women with malaria were enrolled treated artemether-lumefantrine (ALu) at Mkuranga Kisarawe district hospitals...
Intermittent preventive treatment in pregnancy with sulfadoxine‐pyrimethamine (IPTp‐SP) to prevent malaria and adverse birth outcomes is threatened by Plasmodium falciparum resistance sulfadoxine‐pyrimethamine. We investigated the effectiveness of intermittent monthly dihydroartemisinin‐piperaquine (IPTp‐DHP) as an alternative option IPTp‐SP. A total 956 malaria‐free (malaria rapid diagnostic test (MRDT) negative) pregnant women from moderate transmission areas Tanzania were enrolled...
Abstract Background Rheumatic Heart Disease (RHD) continues to cause suffering and premature deaths in many sub-Saharan Africa (SSA) countries, where the disease is still endemic. RHD largely preventable determining its community burden an important critical step any prevention program. Methods We conducted a cross-sectional study of 5–16 years old pupils from 11 primary schools participating program 4 districts Tanzania, between 2018 2019. At school, all children were invited participate...