A5044816280- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Fibroblast Growth Factor Research
- Mycobacterium research and diagnosis
- Eosinophilic Disorders and Syndromes
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Veterinary medicine and infectious diseases
- RNA Research and Splicing
- Galectins and Cancer Biology
University of Miami
2021-2024
Abstract Background: Resistance to chemotherapy remains a significant challenge in the treatment of gastric cancer. This study evaluates therapeutic potential combination FGFR4 inhibitor H3B-6527 and Oxaliplatin preclinical models, focusing on their synergistic effects tumor suppression cell death mechanisms. Material Methods: To evaluate efficacy oxaliplatin combination, we employed IC50 analyses, colony formation assays, patient-derived xenograft (PDX) immunofluorescence (IF),...
Abstract Background: The incidence rate of the esophageal adenocarcinoma (EAC) has increased rapidly among men during past four decades in USA and western countries while 5 year survival is still below 20%. Traditional chemotherapy main stream strategy treatment EAC patients. However, chemo-resistance usually develops that finally leads to failure treatments. NFE2-related factor 2 (NRF2) master regulator cellular anti-oxidant properties maintains cell viability homeostasis. Overexpression...
Abstract Background : H. pylori infection is the main risk factor for gastric cancer. In this study, we investigated -mediated activation of STAT3 and NF-κB in cancer, using vitro vivo models. Methods: To investigate by strains used mouse models, western blots, immunofluorescence, ChIP Assay, luciferase quantitative real-time PCR assays. Results: Following with vitro, found an earlier phosphorylation NF-kB-p65 (S536), followed (Y705). Immunofluorescence, demonstrated nuclear localization...
Abstract Background: Cell cycle dysregulation is a hallmark of cancer, resulting in unregulated cell proliferation and, eventually, tumor development. Cyclin-dependent kinase 1 (CDK1) regulatory protein that involved maintenance. CDK1 has been discovered to be substantially elevated several tumors and linked poor overall relapse-free survival. The aim this study understand the regulation role Helicobacter Pylori infection inflammation on expression gastric cancer. Methods: Using TCGA data...
Abstract Background: Gastric cancer is considered the 5th most common form of and 4th leading cause cancer-related deaths worldwide. Due to late stage diagnosis, gastric carries poor prognosis overall survival. Infection with H. pylori strongest known risk factor. Fibroblast Growth Factor Receptor 4 (FGFR4) belongs a family highly conserved tyrosine kinases. This study investigated molecular mechanism FGFR4 regulation in response infection. Methods Results: Among all FGFRs, mRNA expression...