A5001225766- Innovative Microfluidic and Catalytic Techniques Innovation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Catalysis for Biomass Conversion
- Click Chemistry and Applications
- Chemistry and Chemical Engineering
- Carbon dioxide utilization in catalysis
- Synthesis and Catalytic Reactions
- Organophosphorus compounds synthesis
- Asymmetric Hydrogenation and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Analytical Chemistry and Chromatography
- Enzyme Catalysis and Immobilization
- Oxidative Organic Chemistry Reactions
- Microbial Metabolic Engineering and Bioproduction
- Microfluidic and Capillary Electrophoresis Applications
- Nanomaterials for catalytic reactions
- TiO2 Photocatalysis and Solar Cells
- Advanced Nanomaterials in Catalysis
- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Pesticide and Herbicide Environmental Studies
- Advanced Photocatalysis Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
University of Liège
2016-2025
Walloon Excellence in Lifesciences and Biotechnology
2023-2024
Laboratoire de Synthèse Organique
2015-2021
Fuzhou University
2020
Laboratoire de Chimie Organique
2010-2017
Massachusetts Institute of Technology
2016
Ghent University
1983-2014
University of Florida
2012-2014
UCLouvain
2007-2011
Drug manufacturing in a fridge-sized box Commodity chemicals tend to be manufactured continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account complexity their molecular structures. Adamo et al. now present an apparatus roughly size household refrigerator that can synthesize and purify under continuous-flow conditions (see Perspective Martin). The integrated set modules produce hundreds thousands accumulated doses day, delivered aqueous...
This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on current important societal challenges. These challenges include health/well‐being sustainable development. Continuous has enabled significant advances for manufacturing pharmaceuticals, as well biomass valorization toward biosourced chemical industry. Examples related pharmaceutical production are herein focused (a) implementation reduce...
A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large-scale production bio-based glycerol carbonate under flow conditions. The direct carbonation glycidol with CO
Highly efficient and chemoselective singlet oxygen oxidation of unprotected methionine was performed in water using a continuous mesofluidic reactor. Sustainable process engineering conditions were combined to maximize efficiency atom economy, with virtually no waste generation safe operating conditions. Three water-soluble metal-free photosensitizers [Rose Bengal, Methylene Blue, tetrakis(4-carboxyphenyl)porphyrin] assessed. The best results obtained Rose Bengal (0.1 mol %) at room...
With ever-evolving light-emitting diode (LED) technology, classical photochemical transformations are becoming accessible with more efficient and industrially viable light sources. In combination a triplet sensitizer, we report the detailed exploration of [2 + 2] cycloadditions, in flow, various maleic anhydride derivatives gaseous ethylene. By use flow reactor capable gas handling LED wavelength/power screening, an in-depth optimization these reactions was carried out. particular, highlight...
A review on metal-free and transition metal-based deoxydehydration (DODH) processes for the upgrading of bio-based polyols towards olefins.
SeEA latent selenoester: go fast by switching to selenium.
A robust continuous flow procedure for the transformation of bio-based glycerol into high value-added β-amino alcohol active pharmaceutical ingredients.
Continuous flow preparation of antidepressant ketamine and analogs under sustainable conditions.
The sulfur‐containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report safe effective detoxification of surrogates CEES PhX by selective atom generating peracetic acid from AcOEt aq. H2O2 assisted supported lipase CALB. Morever, it is possible to perform these neutralisations with ‘on demand’ generation AcOOH a flow...
Nitrofurfural is a key building block for the synthesis of antimicrobial nitrofurans as active pharmaceutical ingredients. Its involves nitration furfural, substrate derived from biobased resources. However, furfural has delicate heteroaromatic backbone. Typical nitrations involve harsh reaction conditions, which often compromise this structure, resulting in poor reproducibility and low yields. Although acetyl nitrate, mild nitrating agent, suitable task, major deterrents remain. First, its...
The photooxygenation reaction of olefins was investigated in LED flow reactor module from both experimental and in‐silico point view. Initially, operating parameters potentially affecting the photoreaction efficiency, including loading photosensitizer (methylene blue) (mol%), residence time temperature were screened. optimal conditions then applied for synthesis 1,2‐dioxetanes providing a straightforward scalable approach to important chemiluminescent molecular probes bioanalytical...
The design and construction of an open-source fraction collector its applications in flash column chromatography are described. With the collection vials arranged a circular array, outlet of...
Nitrofurfural is a key building block for the synthesis of antimicrobial nitrofurans as active pharmaceutical ingredients. Its involves nitration furfural, substrate derived from biobased resources. However, furfural has delicate heteroaromatic backbone. Typical nitrations involve harsh reaction conditions, which often compromise this structure, resulting in poor reproducibility and low yields. Although acetyl nitrate, mild nitrating agent, suitable task, major deterrents remain. First, its...
Nitrofurfural is a key building block for the synthesis of antimicrobial nitrofurans as active pharmaceutical ingredients. Its involves nitration furfural, substrate derived from biobased resources. However, furfural has delicate heteroaromatic backbone. Typical nitrations involve harsh reaction conditions, which often compromise this structure, resulting in poor reproducibility and low yields. Although acetyl nitrate, mild nitrating agent, suitable task, major deterrents remain. First, its...