A5033225239- Bone Tumor Diagnosis and Treatments
- Diversity and Career in Medicine
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Advances in Oncology and Radiotherapy
- Medical Education and Admissions
- Ocular Diseases and Behçet’s Syndrome
- Dental Education, Practice, Research
- Surgical Simulation and Training
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- Protease and Inhibitor Mechanisms
- Wound Healing and Treatments
- Cerebral Venous Sinus Thrombosis
- Dermatologic Treatments and Research
- Ubiquitin and proteasome pathways
- Ichthyology and Marine Biology
- Body Contouring and Surgery
- Innovations in Medical Education
- Health and Medical Research Impacts
University of Rochester Medical Center
2023-2024
National Institutes of Health
2020-2024
National Institute of Dental and Craniofacial Research
2020-2024
Louisiana State University Health Sciences Center New Orleans
2020-2022
Bethesda University
2020
National Network of Public Health Institutes
2020
Fibrous dysplasia (FD) is a mosaic skeletal disorder caused by somatic activating variants of GNAS encoding for Gαs and leading to excessive cyclic adenosine monophosphate signaling in bone-marrow stromal cells (BMSCs). The effect activation the BMSC transcriptome how it influences FD lesion microenvironment are unclear. We analyzed changes induced secretome. RNAseq analysis differential gene expression cultured BMSCs from patients with healthy volunteers, an inducible mouse model FD, was...
Of 7461 actively practicing United States American Board of Plastic Surgery certified plastic surgeons, only 17% are women. In relation to this small number, gender inequities within the field have been source national discussions. Our study assessed status gender-based wage-gap in surgery and sought identify possible causes.An anonymous 43-question survey was distributed 2981 members Society Surgeons 2021. Male female responses were compared; an analysis also considering board-certification...
Fibrous dysplasia (FD) is a mosaic skeletal disorder caused by somatic activating variants in
Fibrous dysplasia (FD) is a mosaic skeletal disorder involving the development of benign, expansile fibro-osseous lesions during childhood that cause deformity, fractures, pain, and disability. There are no well-established treatments for FD. Fibroblast activation protein (FAPα) serine protease expressed in pathological fibrotic tissues has promising clinical applications as biomarker local pro-drug activator several conditions. In this study, we explored expression
Abstract Background: Fibrous Dysplasia (FD) is a mosaic disorder that involves fibro-osseous lesions in bone. In the presence of coexisting extra-skeletal features, it termed McCune-Albright Syndrome (MAS). Optic disc edema (ODE) potentially serious finding may progress to optic ischemia and nerve atrophy. We sought determine prevalence identify risk factors for development ODE NIH FD/MAS cohort. Methods: A retrospective review was conducted identified 7 patients with craniofacial diagnosis...
This article reports quantitative measurements of intracranial volume, optic canal area, and peripapillary retinal nerve fiber layer (RNFL) for a cohort 124 patients with craniofacial fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), previously used to determine risks developing disc edema [1]. Of these, 7 subjects were diagnosed edema. OSIRIX imaging analysis software was collect volume diameter 107 patients, via 3D multiplanar reconstruction (MPR) ≤5 mm axial CT slices. Spectral-domain...