A5046277354- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Wireless Power Transfer Systems
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Energy Harvesting in Wireless Networks
- Innovative Energy Harvesting Technologies
- Advanced Battery Technologies Research
- Electrochemical Analysis and Applications
- Microfluidic and Bio-sensing Technologies
- Fuel Cells and Related Materials
- Hydraulic and Pneumatic Systems
- Cardiac Arrhythmias and Treatments
- Prosthetics and Rehabilitation Robotics
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Cardiovascular Syncope and Autonomic Disorders
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
- Muscle activation and electromyography studies
California State University, Northridge
2015-2024
University of California, Los Angeles
2012-2014
La Jolla Bioengineering Institute
2014
UCLA Health
2014
While Fontan palliation in the form of total cavopulmonary connection has improved management congenital single ventricle physiology, long-term outcomes for patients with this disease are suboptimal due to lack two functional ventricles. Researchers have shown that ventricular assist devices (VADs) can normalize hemodynamics. To minimize blood contacting surfaces VAD, we evaluated use an external compression device (C-Pulse Heart Assist System, Sunshine Inc.) as a device. A mock circulation...
Frequency-leveraged electrohydraulic and piezohydraulic pumps represent an alternative technology to traditional electromagnetic motors. The development of a 45 cm3 pump utilizing 2 g low-voltage piezoelectric stack is presented. flow rate performance were measured compared existing in the literature. produced by was nonlinear function operational frequency showing multiple peaks. These peaks accumulator size hydraulic line resonance. capable producing 125 kPa stall pressure, 186 mL min−1...
Piezohydraulic pumps are high power density motors, which can be theoretically miniaturized with minimal loss in output. The feasibility of using piezohydraulic pulsatile pediatric ventricular assist devices is presented this study. A theoretical analysis to calculate the pump dimensions needed meet flow and pressure requirements. In addition, an existing was incorporated into a device driver drive 30-mL stroke as proof concept. tested at heart rates ranging from 50 110 beats per minute...
The current generation of left ventricular assist devices (LVADs) provides continuous flow and has the capacity to reduce aortic pulsatility, which may be related a range complications associated with these devices. Pulsed LVAD operation using speed modulation presents mechanism restore pulsatility potentially mitigate complications. We sought investigate interaction axial centrifugal LVADs LV quantify effects pulsed operations on generated wave patterns under different physiologic...
Changing the speed of left ventricular assist devices (LVADs) cyclically may be useful to restore aortic pulsatility; however, effects this pulsation on right (RV) function are unknown. This study investigates direct interaction by quantifying amount wave energy created RV contraction when axial and centrifugal LVADs used ventricle. In 4 anesthetized pigs, pressure flow were measured in main pulmonary artery intensity analysis was identify quantify waves RV. The pump depressed compared with...
The feasibility of using piezohydraulic pumps in drivers for pediatric ventricular assist devices is presented this article. In study a 0.5 kg pump incorporated into device driver to drive pulsatile 30 mL stroke (VAD). consists piezoelectric-hydraulic hybrid actuator and volume amplification section. Mechanical tests were performed on the maximum power output 5.4 W 1.6 recorded respectively. was tested running at multiple heart rates from 50-80 beats per minute (BPM) an in-vitro bench top...
Right ventricular (RV) dysfunction has limited the effectiveness of mechanical circulatory support (MCS) therapy in some heart failure (HF) patients. Intravascular pumps can provide adequate without need for extensive operations. The development an intravascular right assist device (RVAD), called cavo-arterial pump (CAP), is presented. Two prototypes CAP were developed to demonstrate feasibility providing pulmonary and using axial magnetic couplings contactless torque transmission from motor...
Study: Catheter-deliverable intravascular blood pumps, like the Impella line of products, have been successfully utilized for short-term circulatory support following cardiac infarctions. Broadening use these devices to patients with end-stage heart failure represents a less-invasive alternative. In order achieve more expansive indication use, pump and associated electrical components must be fully-implantable via catheterization. Methods: An prototype its speed controller were miniaturized...
Heart failure (HF) affects approximately 12,000-35,000 children each year in the United States. The development of blood pumps has provided circulatory support for many adults suffering with HF until they receive a heart transplant. However, while led to fullyimplantable continuous flow devices, pump technology lagged significantly behind. One area improving implantability is use wireless powering transfer systems (WPTS). These eliminate power cord connecting implanted external supply. In...
Wave intensity analysis (WIA) as a framework to assess cardiovascular hemodynamics has been successfully used in many clinical applications. Typically, wave calculations require the simultaneous acquisition of blood velocity and pressure at same vascular site. Unfortunately, hemodynamic parameters that are monitor pre-operative patient state use both invasively acquired measurements catheterization laboratory non-invasively measurements. To utilize patients undergoing cardiac interventional...