A5032683106- Fungal and yeast genetics research
- Plant Gene Expression Analysis
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- Nitrogen and Sulfur Effects on Brassica
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Plant Growth Enhancement Techniques
- Plant Physiology and Cultivation Studies
- Transgenic Plants and Applications
- Cancer-related gene regulation
- Neurobiology and Insect Physiology Research
- Fungal Biology and Applications
- Lipid metabolism and biosynthesis
- Potato Plant Research
- Plant Micronutrient Interactions and Effects
- Histone Deacetylase Inhibitors Research
- Genomics, phytochemicals, and oxidative stress
- Ecology and Conservation Studies
- RNA modifications and cancer
Universität Greifswald
2023
Ain Shams University
2018-2023
University of Oxford
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Heidelberg University
2021-2022
Abstract Plants, unlike animals, respond to environmental challenges with comprehensive developmental transitions that allow them cope these stresses. Here we discovered antagonistic activation of the Target Rapamycin (TOR) kinase in Arabidopsis thaliana roots and shoots is essential for nutrient deprivation-induced increase root-to-shoot ratio improve foraging mineral ions. We demonstrate sulfate limitation-induced downregulation TOR activates autophagy, resulting enhanced carbon allocation...
Over the past few decades, a close relationship between sulfur (S) and iron (Fe) in terms of functionality nutrition was demonstrated tomato. However, very little is known about regulatory mechanisms underlying S/Fe interactions. Recently, potential role citrate plant adaptation to Fe deficiency combined S has been described. It that an impaired organic acid metabolism may stimulate retrograde signal, which proven be linked Target Rapamycin (TOR) signaling yeast animal cells. Recent reports...
Abstract Mapping of effective protein domains is a demanding stride to disclose the functional relationship between regulatory complexes. Domain analysis interactions requisite for understanding pleiotropic responses respective partners. Cti6 multifunctional regulator which we could show recruitment co-repressors Sin3, Cyc8 and Tup1. However, responsible core domain tethering these poorly understood. Here, report pivotal that indispensable co-repressor recruitment. We substantiated amino...
Transcriptional corepressors Sin3, Cyc8 and Tup1 are important for downregulation of gene expression by recruiting various histone deacetylases once they gain access to defined genomic locations interaction with pathway-specific repressor proteins. In this work we systematically investigated whether 17 yeast proteins (Cti6, Dal80, Fkh1, Gal80, Mig1, Mot3, Nrg1, Opi1, Rdr1, Rox1, Sko1, Ume6, Ure2, Xbp1, Yhp1, Yox1 Whi5) representing several unrelated regulatory pathways able bind Tup1. Our...
Abstract Transcription factors are inextricably linked with histone deacetylases leading to compact chromatin. The Forkhead transcription factor Fkh1 is mainly a negative transcriptional regulator which affects cell cycle control, silencing of mating-type cassettes and induction pseudohyphal growth in the yeast Saccharomyces cerevisiae . Markedly, impinges chromatin architecture by recruiting large regulatory complexes. Implication corepressor complexes remains largely unexplored. In this...
Under non-inducing conditions (absence of galactose), yeast structural genes the GAL regulon are repressed by Gal80, preventing interaction Gal4 bound to UASGAL promoter motifs with general factors transcriptional machinery. In this work, we show that Gal80 is also able interact histone deacetylase-recruiting corepressor proteins Cyc8 and Tup1, indicating an additional mechanism gene repression. This supported our demonstration a lexA-Gal80 fusion efficiently mediates repression reporter...
The uptake of sulfate by roots and its reductive assimilation mainly in the leaves are not only essential for plant growth development but also defense responses against biotic abiotic stresses. latter functions result stimulus-induced fluctuations sulfur demand at cellular level. However, maintenance acclimation homeostasis local systemic levels is fully understood. Previous research mostly focused on signaling response to external supply roots. Here we apply micrografting Arabidopsis...
Abstract Transcriptional corepressors Sin3, Cyc8 and Tup1 are important for downregulation of gene expression by recruiting various histone deacetylases once they gain access to defined genomic locations interaction with pathway-specific repressor proteins. In this work we systematically investigated whether 17 yeast proteins (Cti6, Dal80, Fkh1, Gal80, Mig1, Mot3, Nrg1, Opi1, Rdr1, Rox1, Sko1, Ume6, Ure2, Xbp1, Yhp1, Yox1 Whi5) representing several unrelated regulatory pathways able bind...