A5023832595- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Chemical Reactions and Isotopes
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Biomedical and Engineering Education
- Radiation Therapy and Dosimetry
- Chemical Synthesis and Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Radioactive Decay and Measurement Techniques
Bioplatforms Australia
2019
Garvan Institute of Medical Research
2017
The Kinghorn Cancer Centre
2017
Significance Radioimmunotherapy is predicated on harnessing the exquisite specificity of antibodies to deliver cytotoxic radiation tumors. Yet long circulation time radioimmunoconjugates leads high doses healthy tissues. Pretargeted radioimmunotherapy (PRIT) circumvents this problem by decoupling antibody and radionuclide, injecting former prior latter, empowering two components combine at tumor. We have leveraged bioorthogonal click chemistry, a colorectal cancer-targeting antibody, pair...
Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism emerged as potentially effective therapeutic strategy for cancers such pancreatic cancer, which are driven by genetic alterations that not tractable drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been observed in various tumors types, understanding metabolic genotype-phenotype relationships is limited. We...
Demand for training life scientists in bioinformatics skills led to the development of a train-the-trainer collaboration between European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI) and 2 Australian organisations, Bioplatforms Australia Commonwealth Scientific Industrial Research Organisation (CSIRO) 2012. The goal was establish group trained instructors who could develop deliver short courses nationally. A course introduces aspects andragogy evidence-based...