A5102830396- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer-related gene regulation
Centre National de la Recherche Scientifique
2020-2023
Institut Jacques Monod
2020-2023
Université Paris Cité
2020-2023
The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in melanoma We found that deletion of NODAL exon 2 a metastatic cell line impairs ability form tumours and colonize distant tissues. However, we show this phenotype does not result from absence but defect expression natural antisense transcript here called LADON. LADON is specifically activated...
Summary The TGFβ family member NODAL, known for its role during embryonic development, has also been associated with tumor progression in several cancers. Some of the evidence supporting involvement melanoma appeared contradictory, suggesting that NODAL this context might rely on a non-canonical signalling mode. We found inactivation metastatic cell line prevents cells from acquiring invasive behaviour. However, we show phenotype does not result absence but defect expression natural...