A5040019252- Vitamin D Research Studies
- Nutritional Studies and Diet
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Obesity, Physical Activity, Diet
- Gastric Cancer Management and Outcomes
- Bone health and osteoporosis research
- Health disparities and outcomes
- Diet and metabolism studies
- Bladder and Urothelial Cancer Treatments
- Multiple and Secondary Primary Cancers
- Economic and Financial Impacts of Cancer
- Cancer Immunotherapy and Biomarkers
- Autopsy Techniques and Outcomes
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Treatments and Mutations
- Insurance, Mortality, Demography, Risk Management
- Colorectal Cancer Treatments and Studies
- Cardiac Arrest and Resuscitation
- Biomarkers in Disease Mechanisms
- Opioid Use Disorder Treatment
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Neutropenia and Cancer Infections
- Bartonella species infections research
Wilmington University
2020-2024
Clinical Insights
2024
Massachusetts General Hospital
2016
Northeastern University
2012-2014
Jean Mayer Human Nutrition Research Center on Aging
2010
In the USA, over 25 million people have asthma; 5%-10% of cases are severe. Mepolizumab (Nucala) is an interleukin-5 antagonist monoclonal antibody; it was approved by FDA in 2015 as add-on maintenance treatment severe asthma for patients aged ≥12 years with eosinophilic phenotype.(1) Describe baseline demographic and clinical characteristics new US adult mepolizumab users 2015-2019, (2) describe medication use 12 months preceding initiation concomitant (3) assess adherence, persistence...
Background: The National Death Index (NDI) is the gold standard for mortality data in United States (US) but has a time lag and can be operationally intensive. This validation study assesses accuracy of various sources with NDI. Methods: secondary analysis an advanced cancer cohort US between January 2010 December 2018, established NDI linkage. Mortality sources, inpatient discharge, disenrollment, death master file (DMF), Center Medicare Medicaid Services (CMS), Utilization management...
ABSTRACT Purpose Many post‐authorization safety studies focus on congenital malformations and rely diagnosis codes found in US data sources. However, no authoritative standards exist for identifying classifying these data. To address this, we translated an existing public health surveillance guide, the European Concerted Action Congenital Anomalies Twins (EUROCAT), into ICD‐10‐CM code list use using administrative healthcare The EUROCAT guide was selected its decisive major or minor...
Abstract Background There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. Methods We conducted a cohort study cancer patients initiating and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (HIRD), longitudinal claims database commercial health plan members in United States. The historical comparator comprised monotherapy January 2011 2015. Propensity score matching Cox...
Associations of either insulin receptor substrate 1 (IRS1) variants or circulating 25-hydroxyvitamin D [25(OH)D] with type 2 diabetes (T2D) and resistance (IR) are inconsistent. This study sought to determine whether 25(OH)D modulates the association a potentially functional variant at IRS1 (rs2943641) resistance.Interaction between rs2943641 on homeostasis model assessment for IR (HOMA-IR) was examined in Boston Puerto Rican Health Study (BPRHS) (n = 1144). Replication performed...
ABSTRACT Purpose We investigated time trends in validation performance characteristics for six sources of death data available within the Healthcare Integrated Research Database (HIRD) over 8 years. Methods conducted a secondary analysis cohort advanced cancer patients with linked National Death Index (NDI) identified HIRD between 2010 and 2018. calculated sensitivity, specificity, positive predictive value, negative value status an algorithm combining from using NDI as reference standard....
BACKGROUND: The treatment landscape for advanced nonsmall cell lung cancer (NSCLC) has evolved from 2015 onward, since the introduction of immune checkpoint inhibitors (ICIs). Considering this shift, there have been limited prior analyses that assess economic burden NSCLC within current landscape. OBJECTIVE: To present an analysis health care resource utilization (HCRU) and costs associated with patients or metastatic in United States between 2010 2019. METHODS: Patients locally who...
Abstract Background Detailed epidemiologic descriptions of large populations advanced stage ovarian cancer patients have been lacking to date. This study aimed describe the patient characteristics, treatment patterns, survival, and incidence rates health outcomes interest (HOI) in a cohort United States (US). Methods identified incident (III/IV) US diagnosed from 2010 2018 HealthCore Integrated Research Database (HIRD) using validated predictive model algorithm. Descriptive characteristics...
Purpose Ascertainment of mortality is critical to epidemiologic studies. Secondary collected database studies face challenges given the need record data in health claims or electronic medical records. The National Death Index (NDI) gold standard for U.S. Methods This study a secondary analysis an advanced cancer cohort between January 2010 and December 2018, with established NDI linkage. Mortality sources, inpatient discharge, disenrollment, death master file (DMF), Center Medicare Medicaid...
Trastuzumab is an antihuman epidermal growth factor receptor 2 monoclonal antibody used to treat breast and other cancers. biosimilars were approved in the United States beginning 2017. Utilization information on these limited.
Abstract Background Currently available medications for chronic osteoarthritis pain are only moderately effective, and their use is limited in many patients because of serious adverse effects contraindications. The primary surgical option total joint replacement (TJR). objectives this study were to describe the treatment history with receiving prescription and/or intra-articular corticosteroid injections, estimate incidence TJR these patients. Methods This retrospective, multicenter, cohort...
Introduction: Pediatric asthma affects 5.5 million US children and is the leading cause of pediatric chronic illness globally. Those with severe have significantly higher healthcare costs compared to those non-severe disease. Biologics are newest class anti-asthma therapy approved for use in patients > 6 years eosinophilic phenotype. Objective: The goals this study were (1) describe baseline characteristics new mepolizumab users between 2015 end dates that varied by data partner...
To assess whether recombinant zoster vaccine (RZV) is associated with an increased risk of new-onset gout among US adults aged ≥50 years.
Abstract Introduction & Objectives There are limited data on peri-partum use of atopic dermatitis (AD) therapies, including for dupilumab, the first AD biologic drug approved by United States (US) Food and Drug Administration. We characterized medication (systemic therapy or phototherapy) among pregnant individuals. Materials Methods Individuals from two US-based commercial health insurance claims databases, Optum Research Database Healthcare Integrated Database, were eligible inclusion...
Puerto Ricans are the second largest Hispanic sub‐group in US; yet there no available data on this population regarding plasma concentrations or dietary sources of vitamin D. We determined 25‐hydroxy D (plasma 25(OH)D) and their associations with key variables, cross‐sectionally, among 1292 Rican adults, 379 men 913 women aged 45–75 years. Dietary from FFQ were used to rank food items by intake contribution. The geometric means for 25(OH)D 15.8 ± 1.5 ng/ml 16.0 women. Our results showed that...
e13082 Background: Our main objective was to identify, in healthcare claims data, patients with advanced or metastatic: urothelial carcinoma (amUC), gastric cancer (amGC) and non-small cell lung (amNSCLC) report on their characteristics, treatments, survival rates using contemporaneous real-world data. Methods: This cohort study conducted the HealthCore Integrated Research Database (HIRD), from January 2010 2018, which contains data commercial health plans across US (60 million lives). We...
Aim: To describe the incidence of safety events after immune checkpoint inhibitor (ICI) initiation for advanced-stage non-small-cell lung cancer. Methods: Retrospective cohort study using HealthCore Integrated Research Database in USA to examine prespecified interest ICI (n = 5278). Results: The most common included malaise/fatigue (incidence rate [IR]: 70.7 per 100 person-years; 95% CI: 66.5-75.1) and nausea/vomiting (IR: 32.4; 30.0-34.8). Other potential immune-mediated events, including...
Introduction This study aimed to assess data relevancy and quality of the Innovation in Medical Evidence Development Surveillance System Distributed Database (IMEDS-DD) for diabetes research evaluate comparability its type 2 cohort general population. Research design methods A retrospective was conducted using IMEDS-DD. Eligible members were adults with a medical encounter between April 1, 2018 March 31, 2019 (index period). Type co-existing conditions determined all available from 2016 most...
Correlation between Cola Consumption and Bone Mineral Density among Puerto Ricans Living in the Greater Boston Area Aziza Jamal‐Allial 1, Katherine L. Tucker 2 1 Health Sciences, Bouvé College of Sciences; Northeastern University. Boston, MA. Clinical Laboratory & Nutritional University Massachusetts Lowell, Several studies have investigated relationship consumption soft drinks bone mineral density (BMD), but results are conflicting. We aimed to study effect drink on BMD at 4 hip...