A5101678761- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Fatty Acid Research and Health
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Gestational Diabetes Research and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Gastric Cancer Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Peroxisome Proliferator-Activated Receptors
- Nicotinic Acetylcholine Receptors Study
- Organ Transplantation Techniques and Outcomes
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
Georgia State University
2023-2024
Guangzhou University of Chinese Medicine
2024
Chongqing Normal University
2023-2024
Institute of Microbiology
2023
Changchun University of Chinese Medicine
2022
University of Pennsylvania
2004
One of the largest sex differences in brain neurochemistry is expression neuropeptide arginine vasopressin (AVP) within vertebrate brain, with males having more AVP cells bed nucleus stria terminalis (BNST) than females. Despite long-standing implication social and anxiety-like behaviors, circuitry underlying AVP’s control these behaviors still not well defined. Using optogenetic approaches, we show that inhibiting BNST reduces investigation males, but females, whereas stimulating increases...
ABSTRACT The cold/hot properties of Chinese materia medica (CMM) are the core theory traditional medicine (TCM). This study aims to investigate CMM and find possible mechanisms related using liquid chromatography‐mass spectrometry (LC‐MS)‐based metabolomics combined with network pharmacology analysis. Typical cold hot CMMs were given mice by intragastric administration. analyses showed that induced metabolome changes modulating arginine proline metabolism, tricarboxylic acid cycle, fatty...
Non-alcoholic steatohepatitis (NASH) is one of the most prevalent diseases worldwide; it characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Here, a Western diet combined with low-dose weekly carbon tetrachloride was fed to C57BL/6J mice for 12 weeks build NASH model investigate attenuating effects possible mechanisms Lactiplantibacillus plantarum LPJZ-658. Hepatic pathology, profiles, gene expression were assessed. The metabolomic profiling serum performed....
To investigate the regulatory effects of simvastatin on inflammation and oxidative stress in rats with cerebral hemorrhage through nuclear factor E2-related 2-antioxidant response element (Nrf2-ARE) signaling pathway.A total 120 healthy male weighing 280-300 g 7-8 weeks old were selected to establish traumatic brain injury (TBI) model. Rats divided into group A (trauma operation, n=30), B (no treatment, C (drug administration after trauma D drug administration, n=30). Cerebral edema content...
This study aimed to investigate the therapeutic effect of black ginseng (BG) on non-alcoholic fatty liver disease (NAFLD) using network pharmacology combined with molecular docking strategy. The saponin composition BG was analyzed by liquid chromatography-mass spectrometry (LC/MS) instrument. Then applied explore potential targets and related mechanisms in treatment NAFLD. After screening out key targets, used predict binding modes between ginsenoside target. Finally, a methionine choline...
Black ginseng (BG) shows beneficial effects on liver injury, but the related mechanism has not been fully revealed. This study attempted to investigate protective and associated mechanisms of BG against nonalcoholic steatohepatitis (NASH). Twelve ginsenosides in were annotated by ultrahigh performance liquid chromatography combined with high resolution mass spectrometry (UHPLC-HRMS). The Western diet (WD) together low-dose CCl4 was given mice create NASH model. Histopathological examination...
Black ginseng (BG) is one type of product, which produced from fresh by steaming and drying several times. To characterize the differences in saponin composition BG white (WG), ultra-high performance liquid chromatography Quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS) was used to analyze samples. A total 53 saponins were successfully identified, possible transformation pathways ginsenosides described. Multivariate statistical analysis methods perform pattern recognition further...
s: 32nd Annual Meeting of the Society Neurosurgical Anesthesia and Critical Care, Las Vegas, Nevada, October 22, 2004: OTHER
Abstract The relationship between conjugated linoleic acid (CLA) and lipogenesis has been extensively studied in mammals some cell lines, but it is relatively rare fish, the potential mechanism of action CLA reducing fat mass remains unclear. established primary culture model for studying grass carp ( Ctenopharyngodon idella ) preadipocytes was used present study, objective to explore effects on intracellular lipid TG content, fatty composition, mRNA levels adipogenesis transcription...
Abstract One of the largest sex differences in brain neurochemistry is male-biased expression neuropeptide arginine vasopressin (AVP) within vertebrate social brain. Despite long-standing implication AVP and anxiety-like behavior, precise circuitry anatomical substrate underlying its control are still poorly understood. By employing optogenetic manipulation cells bed nucleus stria terminalis (BNST), we have unveiled a central role for these promoting investigation, with more pronounced males...
Gordon Holmes syndrome (GHS) is a neurological disorder associated with neuroendocrine, cognitive, and motor impairments corresponding neurodegeneration. Mutations in the E3 ubiquitin ligase RNF216 are strongly linked to GHS. Previous studies show that deletion of Rnf216 mice led sex-specific neuroendocrine dysfunction due disruptions hypothalamic-pituitary-gonadal axis. To address action cognitive functions, we tested knock-out (KO) battery learning tasks for duration 1 year. Although male...