A5048408182- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Marine animal studies overview
- Marine Ecology and Invasive Species
- Insect Pheromone Research and Control
- Effects and risks of endocrine disrupting chemicals
- Marine Bivalve and Aquaculture Studies
- Marine Biology and Ecology Research
- Marine and fisheries research
- Atmospheric and Environmental Gas Dynamics
- Environmental Toxicology and Ecotoxicology
- Turtle Biology and Conservation
- Identification and Quantification in Food
Eastern Research Group (United States)
2020-2024
Harvard University
2016-2019
Massachusetts Institute of Technology
2009
Per- and polyfluoroalkyl substances (PFAS) are a diverse class of fluorinated anthropogenic chemicals that include perfluoroalkyl acids (PFAA), which widely used in modern commerce. Many products environmental samples contain abundant precursors can degrade into terminal PFAA associated with adverse health effects. Fish consumption is an important dietary exposure source for PFAS bioaccumulate food webs. However, little known about bioaccumulation precursors. Here, we identify quantify...
Per- and polyfluoroalkyl substances (PFAS) are a diverse class of highly persistent anthropogenic chemicals that detectable in the serum most humans. PFAS exposure has been associated with many adverse effects on human health including immunotoxicity, increased risk certain cancers, metabolic disruption. binding to abundant blood proteins (human albumin [HSA] globulins) is thought affect transport active sites, toxicity, elimination half-lives. However, few studies have investigated...
Exposure to poly and perfluoroalkyl substances (PFASs) has been associated with adverse health effects in humans wildlife. Understanding pollution sources is essential for environmental regulation but source attribution PFASs confounded by limited information on industrial releases rapid changes chemical production. Here we use principal component analysis (PCA), hierarchical clustering, geospatial understand contributions 14 measured across 37 sites the Northeastern United States 2014. are...
The relative importance of atmospheric versus oceanic transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is not well understood. Vertical profiles from Central shelf water, snow meltwater samples were collected in 2012; 13 PFASs (C6–C12 PFCAs; C6, 8, 10 PFSAs; MeFOSAA EtFOSAA; FOSA) routinely detected (range: <5–343 pg/L). only detectable above 150 m depth polar mixed layer (PML) halocline. Enhanced concentrations observed meltpond samples, implying...
Exposure to poly- and perfluoroalkyl substances (PFASs) has been linked many negative health impacts in humans wildlife. Unlike neutral hydrophobic organic pollutants, PFASs are ionic have hypothesized accumulate both phospholipids protein-rich tissues. Here we investigate the role of for PFAS accumulation by analyzing associations among concurrent measurements phospholipid, total protein, lipid, 24 heart, muscle, brain, kidney, liver, blubber, placenta, spleen North Atlantic pilot whales...
Methylmercury (MeHg) concentrations can increase by 100 000 times between seawater and marine phytoplankton, but levels vary across sites. To better understand how ecosystem properties affect variability in planktonic MeHg concentrations, we develop a model for uptake trophic transfer at the base of food webs. The successfully reproduces measured phytoplankton zooplankton diverse sites from Northwest Atlantic Ocean. Highest are simulated under low dissolved organic carbon (DOC)...
Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported human populations globally following changes production since 2000. However, exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑19PFAS) measured children between 1993 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑19PFAS (ages 5-13 years) peaked 2000 (47.7 ng mL-1) declined significantly by 14.4% year-1 until 2012. Principal component...
Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs human sera, allowing better profiling PFAS exposures. The composition sera reflects the complexity exposure but source identification can be confounded by differences toxicokinetics affecting uptake, distribution, elimination. Common PFASs, such as perfluorooctanoic...
Poly- and perfluoroalkyl substances (PFASs) are persistent, bioaccumulative anthropogenic compounds associated with adverse health impacts on humans wildlife. PFAS production changed in North America Europe around the year 2000, but wildlife appear to vary across species location. Unlike other mammal species, cetaceans lack enzyme for transforming an important intermediate precursor (perfluorooctane sulfonamide: FOSA), into a prevalent compound most (perfluorooctanesulfonate: PFOS). Thus,...
Abstract Perfluorooctane sulfonate (PFOS) is an aliphatic fluorinated compound with eight carbon atoms that extremely persistent in the environment and can adversely affect human ecological health. The stability, low reactivity, high water solubility of PFOS combined North American phaseout production around year 2000 make it a potentially useful new tracer for ocean circulation. Here we characterize processes affecting lifetime accumulation Atlantic Ocean transport to sensitive Arctic...