A5018572732- Malaria Research and Control
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Diverse Scientific Research Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Cancer therapeutics and mechanisms
- Toxoplasma gondii Research Studies
- Computational Drug Discovery Methods
Stanford University
2024
Jawaharlal Nehru University
2020
Antimalarial drug resistance is a serious obstacle in the persistent quest to eradicate malaria. There need for potent chemical agents that are able act on drug-resistant Plasmodium falciparum populations at reasonable concentrations without any related toxicity host. By rational design, we envisaged address this issue by generating novel hybrid possessing two pharmacophores can unique and independent targets within cell. We synthesized new class of ciprofloxacin-based molecules, which have...
Artemisinin is a remarkable compound whose derivatives and combinations with multiple drugs have been utilized at the forefront of malaria treatment. However, inherent issues parent such as poor bioavailability, short serum half-life, high first-pass metabolism partially limit further applications this drug. In study, we enhanced aqueous phase solubility artemisinin by encapsulating it in two nanocarriers based on polymer polycaprolactone (ART-PCL) lipid-based Large Unilamellar Vesicles...