A5032561255- Ion channel regulation and function
- Fuel Cells and Related Materials
- Anesthesia and Sedative Agents
- EEG and Brain-Computer Interfaces
- Trigeminal Neuralgia and Treatments
- Advanced Battery Technologies Research
- Nanopore and Nanochannel Transport Studies
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Maternal and fetal healthcare
- Neural dynamics and brain function
- Lipid Membrane Structure and Behavior
- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrocatalysts for Energy Conversion
University of Fukui
2010-2021
University of Fukui Hospital
2016
Regional Medical Center
2015
Significance Ion selectivity is a fundamental property of ion channels. Potassium channels exhibit an unusual selectivity, allowing passage larger K + ions (ionic radius 1.3 Å) over smaller Na (1.0 Å); the mechanism underlying small rejecting remains unknown. Here, we applied as probe for examining pore prototypical potassium channel and found slight conduction across pore. traced tortuous trajectory in narrow pore, with multiple trapped here there, leading to slow elution. Contrarily,...
KcsA is a tetrameric K+ channel that activated by acidic pH. Under open conditions of the helix bundle crossing, selectivity filter undergoes an equilibrium between permeable and impermeable conformations. Here we report population conformation (pperm) positively correlates with stability in reconstituted high density lipoprotein, where surrounded lipid bilayer, lower than detergent micelles, indicating dynamic properties are different these two media. Perturbation membrane environment...
A hydrogen-bonded water-chain in a nanotube is highly proton conductive, and examining the flux under electric fields crucial to understanding one-dimensional Grotthuss conduction. Here, we exploited nanotube-forming natural product, peptide polytheonamide B (pTB), examine conduction mechanisms at single-molecule level. The pTB has length of ∼40 Å that spans membrane uniform inner diameter 4 holds single-file water-chain. Single-channel currents were measured using planar lipid bilayers...
P61Mechamsm