A5031569747- Advanced Glycation End Products research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Xenotransplantation and immune response
- Medical and Biological Ozone Research
- Sperm and Testicular Function
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
Oslo University Hospital
2018-2021
University of Oslo
2018-2021
Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism xenograft rejection. We hypothesized that complement component C5 and TLR co-receptor CD14 inhibition would inhibit porcine cornea induced responses. Therefore, we measured cytokine release human blood, by three forms xenografts with or without inhibitors. Native (NPC) interleukins (IL-1β, IL-2, IL-6, IL-8, IL-1ra),...
Abstract Studies in mice and humans have shown that CD8 + T cell immunosurveillance non-lymphoid tissues is dominated by resident populations. Whether CD4 cells use the same strategies to survey peripheral less clear. Here, examining turnover of transplanted duodenum humans, we demonstrate majority were still donor-derived one year after transplantation. In contrast memory blood, intestinal RM expressed CD69 CD161, but only a minor fraction CD103. Functionally, very potent cytokine...